Cotrimoxazole - optimal dosing in the critically ill

RT @dr_shai: @PulmCrit @accpchest The rate of AKI with high dose therapy is 10-20% in the studies I have seen. My clinical experience- clo…

@PulmCrit @accpchest The rate of AKI with high dose therapy is 10-20% in the studies I have seen. My clinical experience- close to 100% - but they have all been quite sick, so high RF burden. Sensible dosing is a must. https://t.co/8N2rHITn8M

@PulmCrit https://t.co/zmbwWd1oUW this one is a nice review about TMP dosing

RT @kartc: @BradSpellberg @IdVilchez @DrToddLee @BJegorovic @ABsteward @PaulSaxMD @wfwrighID @IDstewardship TMP-SMX dosing in critically il…

RT @kartc: @BradSpellberg @IdVilchez @DrToddLee @BJegorovic @ABsteward @PaulSaxMD @wfwrighID @IDstewardship TMP-SMX dosing in critically il…

@BradSpellberg @IdVilchez @DrToddLee @BJegorovic @ABsteward @PaulSaxMD @wfwrighID @IDstewardship TMP-SMX dosing in critically ill patients is another story. Vd of TMP is higher than SMX, drug accumulation etc. https://t.co/SxwlBSGfhF

@IDPharmacometrx @BradSpellberg @serotavirus @jasonroberts_pk Hmmm.. "For pathogens with lower target concentrations Cmin concentrations for TMP of above 2 mcg/ml can be maintained with a dosage of 160 mg TMP twice daily." https://t.co/ZDwYB1Ul8H

ICYMI #Cotrimoxazole dosing in the critically ill - poorly investigated #criticalcare #PKPD http://t.co/MYbbIHdcgp #sepsis