| Title |
Cotrimoxazole - optimal dosing in the critically ill
|
|---|---|
| Published in |
Annals of Intensive Care, April 2014
|
| DOI | 10.1186/2110-5820-4-13 |
| Pubmed ID | |
| Authors |
Glen R Brown |
| Abstract |
The optimum dosage regimen for cotrimoxazole in the treatment of life threatening infections due to susceptible organisms encountered in critically ill patients is unclear despite decades of the drug's use. Therapeutic drug monitoring to determine the appropriate dosing for successful infection eradication is not widely available. The clinician must utilize published pharmacokinetic, pharmacodynamic, and effective inhibitory concentration information to determine potential dosing regimens for individual patients when treating specific pathogens. Using minimum inhibitory concentrations known to successfully block growth for target pathogens, the pharmacokinetics of both trimethoprim and sulfamethoxazole can be utilized to establish empiric dosing regimens for critically ill patients while considering organ of clearance impairment. The author's recommendations for appropriate dosing regimens are forwarded based on these parameters. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 13% |
| Chile | 1 | 13% |
| United States | 1 | 13% |
| Canada | 1 | 13% |
| Belgium | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 103 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 18% |
| Researcher | 15 | 14% |
| Other | 14 | 13% |
| Student > Master | 12 | 11% |
| Student > Postgraduate | 8 | 8% |
| Other | 17 | 16% |
| Unknown | 20 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 40% |
| Pharmacology, Toxicology and Pharmaceutical Science | 19 | 18% |
| Agricultural and Biological Sciences | 7 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Chemistry | 3 | 3% |
| Other | 5 | 5% |
| Unknown | 25 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2024.
All research outputs
#3,183,846
of 25,651,057 outputs
Outputs from Annals of Intensive Care
#435
of 1,208 outputs
Outputs of similar age
#30,575
of 242,677 outputs
Outputs of similar age from Annals of Intensive Care
#3
of 7 outputs
Altmetric has tracked 25,651,057 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,208 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.3. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,677 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.