| Title |
Bipolar disorder and diabetes mellitus: evidence for disease-modifying effects and treatment implications
|
|---|---|
| Published in |
International Journal of Bipolar Disorders, July 2016
|
| DOI | 10.1186/s40345-016-0054-4 |
| Pubmed ID | |
| Authors |
Ellen F. Charles, Christophe G. Lambert, Berit Kerner |
| Abstract |
Bipolar disorder refers to a group of chronic psychiatric disorders of mood and energy levels. While dramatic psychiatric symptoms dominate the acute phase of the diseases, the chronic course is often determined by an increasing burden of co-occurring medical conditions. High rates of diabetes mellitus in patients with bipolar disorder are particularly striking, yet unexplained. Treatment and lifestyle factors could play a significant role, and some studies also suggest shared pathophysiology and risk factors. In this systematic literature review, we explored data around the relationship between bipolar disorder and diabetes mellitus in recently published population-based cohort studies with special focus on the elderly. A systematic search in the PubMed database for the combined terms "bipolar disorder" AND "elderly" AND "diabetes" in papers published between January 2009 and December 2015 revealed 117 publications; 7 studies were large cohort studies, and therefore, were included in our review. We found that age- and gender- adjusted risk for diabetes mellitus was increased in patients with bipolar disorder and vice versa (odds ratio range between 1.7 and 3.2). Our results in large population-based cohort studies are consistent with the results of smaller studies and chart reviews. Even though it is likely that heterogeneous risk factors may play a role in diabetes mellitus and in bipolar disorder, growing evidence from cell culture experiments and animal studies suggests shared disease mechanisms. Furthermore, disease-modifying effects of bipolar disorder and diabetes mellitus on each other appear to be substantial, impacting both treatment response and outcomes. The risk of diabetes mellitus in patients with bipolar disorder is increased. Our findings add to the growing literature on this topic. Increasing evidence for shared disease mechanisms suggests new disease models that could explain the results of our study. A better understanding of the complex relationship between bipolar disorder and diabetes mellitus could lead to novel therapeutic approaches and improved outcomes. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 27% |
| Japan | 1 | 9% |
| Venezuela, Bolivarian Republic of | 1 | 9% |
| Egypt | 1 | 9% |
| United States | 1 | 9% |
| Unknown | 4 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 73% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 15% |
| Student > Master | 14 | 12% |
| Researcher | 12 | 11% |
| Other | 9 | 8% |
| Student > Postgraduate | 9 | 8% |
| Other | 20 | 18% |
| Unknown | 32 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 28% |
| Nursing and Health Professions | 11 | 10% |
| Psychology | 7 | 6% |
| Neuroscience | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 20 | 18% |
| Unknown | 32 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2023.
All research outputs
#1,595,870
of 24,677,985 outputs
Outputs from International Journal of Bipolar Disorders
#37
of 315 outputs
Outputs of similar age
#29,459
of 362,755 outputs
Outputs of similar age from International Journal of Bipolar Disorders
#2
of 4 outputs
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So far Altmetric has tracked 315 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one has done well, scoring higher than 88% of its peers.
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