Title |
The human "magnesome": detecting magnesium binding sites on human proteins
|
---|---|
Published in |
BMC Bioinformatics, September 2012
|
DOI | 10.1186/1471-2105-13-s14-s10 |
Pubmed ID | |
Authors |
Damiano Piovesan, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio |
Abstract |
Magnesium research is increasing in molecular medicine due to the relevance of this ion in several important biological processes and associated molecular pathogeneses. It is still difficult to predict from the protein covalent structure whether a human chain is or not involved in magnesium binding. This is mainly due to little information on the structural characteristics of magnesium binding sites in proteins and protein complexes. Magnesium binding features, differently from those of other divalent cations such as calcium and zinc, are elusive. Here we address a question that is relevant in protein annotation: how many human proteins can bind Mg2+? Our analysis is performed taking advantage of the recently implemented Bologna Annotation Resource (BAR-PLUS), a non hierarchical clustering method that relies on the pair wise sequence comparison of about 14 millions proteins from over 300.000 species and their grouping into clusters where annotation can safely be inherited after statistical validation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 17% |
Japan | 3 | 10% |
Germany | 1 | 3% |
Unknown | 20 | 69% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 26 | 90% |
Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Canada | 1 | 2% |
Australia | 1 | 2% |
Unknown | 46 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 27% |
Researcher | 12 | 24% |
Student > Bachelor | 4 | 8% |
Student > Doctoral Student | 3 | 6% |
Student > Master | 3 | 6% |
Other | 4 | 8% |
Unknown | 10 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 37% |
Agricultural and Biological Sciences | 7 | 14% |
Chemistry | 5 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Medicine and Dentistry | 2 | 4% |
Other | 5 | 10% |
Unknown | 10 | 20% |