Title |
Inhibition of cytosolic Phospholipase A2prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin
|
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Published in |
BMC Neuroscience, August 2012
|
DOI | 10.1186/1471-2202-13-106 |
Pubmed ID | |
Authors |
Victoria Last, Alun Williams, Dirk Werling |
Abstract |
Activation of phospholipase A2 (PLA2) and the subsequent metabolism of arachidonic acid (AA) to prostaglandins have been shown to play an important role in neuronal death in neurodegenerative disease. Here we report the effects of the prion peptide fragment HuPrP106-126 on the PLA2 cascade in primary cortical neurons and translocation of cPLA2 to neurites. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 3% |
Germany | 1 | 3% |
Unknown | 38 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 25% |
Student > Master | 7 | 18% |
Student > Bachelor | 6 | 15% |
Student > Ph. D. Student | 5 | 13% |
Student > Doctoral Student | 2 | 5% |
Other | 4 | 10% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 25% |
Agricultural and Biological Sciences | 10 | 25% |
Chemistry | 3 | 8% |
Medicine and Dentistry | 2 | 5% |
Neuroscience | 2 | 5% |
Other | 5 | 13% |
Unknown | 8 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2012.
All research outputs
#18,313,878
of 22,675,759 outputs
Outputs from BMC Neuroscience
#878
of 1,240 outputs
Outputs of similar age
#130,374
of 170,196 outputs
Outputs of similar age from BMC Neuroscience
#24
of 38 outputs
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So far Altmetric has tracked 1,240 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.