Title |
Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells
|
---|---|
Published in |
Inflammation, May 2015
|
DOI | 10.1007/s10753-015-0172-7 |
Pubmed ID | |
Authors |
Dunjing Wang, Jun Shi, Shuiqing Lv, Weiwei Xu, Jizhen Li, Wei Ge, Chenghua Xiao, Deqin Geng, Yonghai Liu |
Abstract |
Microglia are considered as a major target in the prevention of neuroinflammation by modulating the production of pro-inflammatory mediators. Artesunate, a water-soluble artemisinin derivative, exerts an anti-inflammatory effect. In the present study, we showed artesunate dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), and interleukin-1beta (IL-1β) in BV2 microglial cells. In addition, artesunate inhibited LPS-induced expression of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and activation of nuclear factor kappa B (NF-κB) by blockade of inhibitor of NF-κB (IκB) degradation. This data indicate that artesunate attenuates the generation of proinflammatory mediators on LPS-stimulated BV-2 microglial cells. And this effect may be associated with the suppression of TLR4/MyD88/NF-κB signaling pathways. Therefore, artesunate may be a potential anti-neuroinflammatory agent. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 24% |
Student > Bachelor | 2 | 8% |
Student > Master | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Professor | 1 | 4% |
Other | 3 | 12% |
Unknown | 10 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 24% |
Immunology and Microbiology | 3 | 12% |
Neuroscience | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |