Title |
18F-fluoride-PET for dynamic in vivo monitoring of bone formation in multiple myeloma
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Published in |
EJNMMI Research, May 2016
|
DOI | 10.1186/s13550-016-0197-4 |
Pubmed ID | |
Authors |
J. C. Regelink, P. G. Raijmakers, N. Bravenboer, R. Milek, N. J. Hoetjes, A. M. de Kreuk, M. van Duin, M. J. Wondergem, P. Lips, P. Sonneveld, J. M. Zijlstra, S. Zweegman |
Abstract |
Bone disease in multiple myeloma is characterized by reduced bone formation. The gold standard of bone formation is the mineral apposition rate (MAR), an invasive technique reflecting bone formation at a single site. We compared (18)F-fluoride-PET with the MAR in myeloma patients. Bone formation was measured before and after bortezomib treatment by determination of the MAR in iliac bone marrow biopsies and the measurement of (18)F-uptake. The inter- and intra-individual variations in (18)F-uptake (SUVA50%) were pronounced as 33.50 (range 4.42 to 37.92) and 27.18 (range 4.00 to 31.18), respectively. A significant correlation between the MAR and (18)F-uptake was found (r = 0.80, p = 0.017). There was a heterogeneous response after treatment varying from -2.20 to 4.53. Iliac (18)F-uptake was associated with the local MAR in myeloma patients. Furthermore, (18)F-fluoride-PET demonstrated the heterogeneity of in vivo bone formation, enabling monitoring during treatment. |
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Demographic breakdown
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Other | 2 | 13% |
Student > Doctoral Student | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Student > Bachelor | 1 | 6% |
Other | 2 | 13% |
Unknown | 4 | 25% |
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Engineering | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 25% |