| Title |
Lipid Abnormalities and Inflammation in HIV Inflection
|
|---|---|
| Published in |
Current HIV/AIDS Reports, May 2016
|
| DOI | 10.1007/s11904-016-0321-0 |
| Pubmed ID | |
| Authors |
Nicholas T. Funderburg, Nehal N. Mehta |
| Abstract |
Infection with the human immunodeficiency virus (HIV), and subsequent treatment with antiretroviral therapy (ART), is often associated with perturbations in lipid profiles. Furthermore, persistent inflammation, in spite of suppression of viral replication by ART, likely contributes to modifications in lipid composition and function, exacerbating risk for development of cardiovascular disease (CVD). Increased levels of several pro-inflammatory lipid species, including oxidized low-density lipoprotein (LDL) and high-density lipoprotein (HDL), have been measured in HIV-infected persons and are associated with markers of immune activation. The mechanisms linked to this bidirectional relationship in which inflammation increases lipid levels and promotes their modification, and these modified lipid species perpetuate inflammatory processes, require further investigation. Treatment with statins and other lifestyle modifications, including improvement in dietary intake and exercise, are critical to reducing CVD risk. Well-designed clinical trials that take into account the complex relationships among lipids and inflammation within persons infected with HIV need to be considered. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 147 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Unknown | 146 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Postgraduate | 17 | 12% |
| Student > Ph. D. Student | 16 | 11% |
| Student > Master | 15 | 10% |
| Student > Doctoral Student | 11 | 7% |
| Researcher | 10 | 7% |
| Other | 28 | 19% |
| Unknown | 50 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 27% |
| Agricultural and Biological Sciences | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 10 | 7% |
| Nursing and Health Professions | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 16 | 11% |
| Unknown | 54 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2023.
All research outputs
#14,545,962
of 25,795,662 outputs
Outputs from Current HIV/AIDS Reports
#286
of 477 outputs
Outputs of similar age
#176,835
of 354,897 outputs
Outputs of similar age from Current HIV/AIDS Reports
#7
of 10 outputs
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