| Title |
Impact of central obesity on prognostic outcome of triple negative breast cancer in Chinese women
|
|---|---|
| Published in |
SpringerPlus, May 2016
|
| DOI | 10.1186/s40064-016-2200-y |
| Pubmed ID | |
| Authors |
Hong-liang Chen, Ang Ding, Mao-li Wang |
| Abstract |
To evaluate the prognostic effect of central obesity on triple negative breast cancer (TNBC). 206 TNBC patients treated from June 2006 to June 2015 were enrolled retrospectively. Body mass index (BMI) ≥25 kg/m(2) was the standard of obesity and waist circumference ≥80 cm was the standard of central obesity. Patient and tumor characteristics were compared between obesity categories. Survival differences between obesity categories were assessed with log-rank test in the univariate analysis and prognostic factors were then investigated by Cox regression analysis. 81 cases were with obesity (39.3 %). 71 cases were with central obesity (34.5 %). Patients with obesity or central obesity tended to be older (P = 0.022 for obesity; P = 0.013 for central obesity) and to have larger tumor size (P = 0.027 for obesity; P = 0.027 for central obesity). By Cox regression analysis, central obesity (DFS: HR 1.759; 95 % CI 1.009-3.065; P = 0.046. OS: HR 2.297; 95 % CI 1.184-4.456; P = 0.014) was identified as an independent prognostic factor. For central obesity with BMI ≥ 25 kg/m(2), the prognostic effect was more apparent (DFS: HR 1.845; 95 % CI 1.059-3.212; P = 0.031. OS: HR 2.377; 95 % CI 1.230-4.593; P = 0.010). Central obesity, especially with high BMI, was an independent prognostic factor for TNBC. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 16% |
| Student > Doctoral Student | 3 | 12% |
| Student > Bachelor | 2 | 8% |
| Student > Ph. D. Student | 2 | 8% |
| Researcher | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 10 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 32% |
| Biochemistry, Genetics and Molecular Biology | 2 | 8% |
| Arts and Humanities | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Immunology and Microbiology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 11 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2016.
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#20,330,976
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Outputs from SpringerPlus
#1,460
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#263,495
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Outputs of similar age from SpringerPlus
#149
of 184 outputs
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