| Title |
Systematic evaluation of 99mTc-tetrofosmin versus 99mTc-sestamibi to study murine myocardial perfusion in small animal SPECT/CT
|
|---|---|
| Published in |
EJNMMI Research, May 2012
|
| DOI | 10.1186/2191-219x-2-21 |
| Pubmed ID | |
| Authors |
Alexis Vrachimis, Sven Hermann, Domokos Máthé, Otmar Schober, Michael Schäfers |
| Abstract |
The "back-translation" of clinically available protocols to measure myocardial perfusion to preclinical imaging in mouse models of human disease is attractive for basic biomedical research. With respect to single-photon emission computed tomography (SPECT) approaches, clinical myocardial perfusion imaging protocols are established with different 99mTc-labeled perfusion tracers; however, studies evaluating and optimizing protocols for these tracers in high-resolution pinhole SPECT in mice are lacking. This study aims at evaluating two clinically available 99mTc-labeled myocardial perfusion tracers (99mTc-sestamibi vs. 99mTc-Tetrofosmin) in mice using four different imaging protocols. |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 6% |
| Germany | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 29 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 24% |
| Researcher | 6 | 18% |
| Student > Bachelor | 4 | 12% |
| Other | 3 | 9% |
| Student > Master | 3 | 9% |
| Other | 4 | 12% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 42% |
| Agricultural and Biological Sciences | 4 | 12% |
| Physics and Astronomy | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Other | 4 | 12% |
| Unknown | 7 | 21% |