Inhibition of lysosomal enzyme activities by proton pump inhibitors

@farid__jalali Such ROS issues might arise from e.g. inhibiting the proton pumps used by lysosomes. https://t.co/EqTUpqXYei PPIs have also been noted to impair endothelial function, reduce telomere length, and induce senescence in related cell culture:

@PeterKolchinsky Proton pumps in lysosomes. “Our data support the hypothesis that many of the PPI adverse effects are caused by systematically compromised immunity, a result of PPI inhibition of the lysosomal enzymes.” https://t.co/MCjWPQ5pyf