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Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome

Overview of attention for article published in EJNMMI Research, May 2016
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  • Among the highest-scoring outputs from this source (#48 of 168)
  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

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3 tweeters

Citations

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4 Dimensions

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12 Mendeley

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Title
Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome
Published in
EJNMMI Research, May 2016
DOI 10.1186/s13550-016-0196-5
Pubmed ID
27169534
Authors

Atsuro Masuda, Keiichiro Yoshinaga, Masanao Naya, Osamu Manabe, Satoshi Yamada, Hiroyuki Iwano, Tatsuya Okada, Chietsugu Katoh, Yasuchika Takeishi, Hiroyuki Tsutsui, Nagara Tamaki

Abstract

Accelerated clearance of (99m)technetium-sestamibi (MIBI) has been observed after reperfusion therapy in patients with acute coronary syndrome (ACS), but the mechanisms have not been fully investigated. MIBI retention may depend on mitochondrial function. The clearance rate of (11)carbon-acetate reflects such mitochondrial functions as oxidative metabolism. The purpose of this study was to examine the mechanisms of accelerated MIBI clearance in ACS. We therefore compared it to oxidative metabolism estimated using (11)C-acetate positron emission tomography (PET). Eighteen patients [mean age 69.2 ± 8.7 years, 10 males (56 %)] with reperfused ACS underwent MIBI single-photon emission computed tomography (SPECT), echocardiography, and (11)C-acetate PET within 3 weeks of the onset of ACS. MIBI images were obtained 30 min and 3 h after MIBI administration. Regional left ventricular (LV) function was evaluated by echocardiography. The measurement of oxidative metabolism was obtained through the mono-exponential fitting of the (11)C-acetate time-activity curve (k mono). Among 95 segments of reperfused myocardium, MIBI SPECT showed 64 normal segments (group N), 14 segments with accelerated MIBI clearance (group AC), and 17 segments with fixed defect (group F). Group AC showed lower k mono than group N (0.041 ± 0.009 vs 0.049 ± 0.010, p = 0.02). Group F showed lower k mono than group N (0.039 ± 0.012 vs 0.049 ± 0.010, p = 0.01). However, k mono was similar in group AC and group F (p = 0.99). Segments with accelerated MIBI clearance showed reduced oxidative metabolism in ACS. Loss of MIBI retention may be associated with mitochondrial dysfunction.

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Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 25%
Student > Ph. D. Student 3 25%
Researcher 2 17%
Student > Bachelor 1 8%
Student > Postgraduate 1 8%
Other 0 0%
Unknown 2 17%
Readers by discipline Count As %
Medicine and Dentistry 5 42%
Biochemistry, Genetics and Molecular Biology 2 17%
Nursing and Health Professions 1 8%
Agricultural and Biological Sciences 1 8%
Neuroscience 1 8%
Other 0 0%
Unknown 2 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2016.
All research outputs
#4,001,378
of 7,719,347 outputs
Outputs from EJNMMI Research
#48
of 168 outputs
Outputs of similar age
#146,450
of 269,633 outputs
Outputs of similar age from EJNMMI Research
#2
of 6 outputs
Altmetric has tracked 7,719,347 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 168 research outputs from this source. They receive a mean Attention Score of 1.5. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,633 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.

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