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Importance of infarct size versus other variables for clinical outcomes after PPCI in STEMI patients

Overview of attention for article published in Basic Research in Cardiology, December 2019
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Title
Importance of infarct size versus other variables for clinical outcomes after PPCI in STEMI patients
Published in
Basic Research in Cardiology, December 2019
DOI 10.1007/s00395-019-0764-8
Pubmed ID
Authors

Thomas Bochaton, Marc J. Claeys, David Garcia-Dorado, Nathan Mewton, Cyrille Bergerot, Claire Jossan, Camille Amaz, Inesse Boussaha, Hélène Thibault, Michel Ovize

Abstract

Despite promising experimental studies and encouraging proof-of-concept clinical trials, interventions aimed at limiting infarct size have failed to improve clinical outcomes in patients with ST-elevation myocardial infarction (STEMI). Our objective was to examine whether variables (cardiovascular risk factors, comorbidities, post-procedural variables, cotreatments) might be associated with clinical outcomes in STEMI patients independently from infarct size reduction. The present study was based on a post hoc analysis of the CIRCUS trial database (Clinicaltrials.gov NCT01502774) that assessed the clinical benefit of a single intravenous bolus of cyclosporine in 969 patients with anterior STEMI. Since cyclosporine had no detectable effect on clinical outcomes as well as on any measured variable, we here considered the whole study population as one group. Multivariate analysis was performed to address the respective weight of infarct size and variables in clinical outcomes. Multivariate analysis revealed that several variables (including gender, hypertension, renal dysfunction, TIMI flow grade post-PCI < 3, and treatment administered after PCI with betablockers and angiotensin-converting enzyme inhibitors) had per se a significant influence on the occurrence of [death or hospitalization for heart failure] at 1 year. The relative weight of infarct size and variables on the composite endpoint of [death or hospitalization for heart failure] at 1 year was 18% and 82%, respectively. Several variables contribute strongly to the clinical outcomes of STEMI patients suggesting that cardioprotective strategy might not only focus on infarct size reduction.

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Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2019.
All research outputs
#8,513,626
of 14,143,289 outputs
Outputs from Basic Research in Cardiology
#271
of 447 outputs
Outputs of similar age
#152,631
of 277,532 outputs
Outputs of similar age from Basic Research in Cardiology
#3
of 9 outputs
Altmetric has tracked 14,143,289 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 447 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,532 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.