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α-Synucleinopathy in the human olfactory system in Parkinson’s disease: involvement of calcium-binding protein- and substance P-positive cells

Overview of attention for article published in Acta Neuropathologica, April 2010
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Title
α-Synucleinopathy in the human olfactory system in Parkinson’s disease: involvement of calcium-binding protein- and substance P-positive cells
Published in
Acta Neuropathologica, April 2010
DOI 10.1007/s00401-010-0687-9
Pubmed ID
Authors

Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Carlos de la Rosa-Prieto, Lucia Argandoña-Palacios, Susana Garcia-Muñozguren, Alino Martinez-Marcos

Abstract

Hyposmia is an early symptom of idiopathic Parkinson's disease but the pathological bases of such dysfunction are largely unknown. The distribution of alpha-synuclein, which forms Lewy bodies and Lewy neurites, and the types of neurons (based on their neurotransmitters) affected by alpha-synucleinopathy were investigated in the olfactory system in Parkinson's disease. Immunohistochemical distribution of alpha-synuclein and its co-localization with tyrosine hydroxylase, somatostatin, calbindin, calretinin, parvalbumin and substance P in the olfactory bulb, anterior olfactory nucleus, olfactory tubercle and piriform, periamygdaloid and rostral entorhinal cortices of idiopathic Parkinson's disease cases (n = 11) and age-matched controls (n = 11) were investigated. Lewy bodies and Lewy neurites were present in the olfactory bulb, particularly in mitral cells and in the inner plexiform layer. alpha-synuclein was particularly abundant in the different divisions of the anterior olfactory nucleus (bulbar, intrapeduncular, retrobulbar and cortical). In contrast, Lewy bodies and Lewy neurites were less abundant in the olfactory tubercle and olfactory cortices. In the olfactory bulb, anterior olfactory nucleus and olfactory cortices, cells affected by alpha-synucleinopathy rarely co-localized tyrosine hydroxylase or somatostatin, but they frequently co-localized calbindin, calretinin, parvalbumin and substance P. The present data provide evidence that alpha-synucleinopathy affects neurons along the olfactory pathway. Dopamine- and somatostatin-positive cells are rarely affected; whereas the cell types most vulnerable to neurodegeneration include glutamate- (mitral cells), calcium-binding protein- and substance P-positive cells. These results provide data on the distribution and cell types involved by alpha-synucleinopathy in the human olfactory system during Parkinson disease that may be useful for future clinical investigation.

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Mendeley readers

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The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Germany 1 1%
Unknown 79 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 21 26%
Student > Bachelor 13 16%
Student > Ph. D. Student 12 15%
Student > Master 8 10%
Student > Doctoral Student 6 7%
Other 15 18%
Unknown 7 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 28%
Neuroscience 23 28%
Medicine and Dentistry 16 20%
Biochemistry, Genetics and Molecular Biology 4 5%
Psychology 3 4%
Other 4 5%
Unknown 9 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2012.
All research outputs
#15,243,120
of 22,664,644 outputs
Outputs from Acta Neuropathologica
#2,094
of 2,357 outputs
Outputs of similar age
#77,004
of 94,716 outputs
Outputs of similar age from Acta Neuropathologica
#19
of 20 outputs
Altmetric has tracked 22,664,644 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
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