Title |
Role of steroid hormones and morphine treatment in the modulation of opioid receptor gene expression in brain structures in the female rat
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Published in |
SpringerPlus, July 2015
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DOI | 10.1186/s40064-015-1021-8 |
Pubmed ID | |
Authors |
Wesley Soares Cruz, Lucas Assis Pereira, Luana Carvalho Cezar, Rosana Camarini, Luciano Freitas Felicio, Maria Martha Bernardi, Elizabeth Teodorov |
Abstract |
This study determined the effects of acute treatment with morphine on the expression of the Oprm1, Oprk1, and Oprd1 genes (which encode μ, κ, and δ receptors, respectively) in the striatum, hypothalamus, and periaqueductal gray (PAG) in ovariectomized female rats treated with estrogen. Ovariectomized female rats were divided into five equal groups. Two groups received estrogen (50 µg/kg, 54 h before testing) and saline (ES group) or 3.5 mg/kg morphine (EM group) 2 h before euthanasia. The SS group received saline solution 54 and 2 h before the experiments. The SM group received saline 54 h and 3.5 mg/kg morphine 2 h before the experiments. The W group remained undisturbed. The genes expression were evaluated. Oprm1 and Oprk1 expression were activated, respectively, in the hypothalamus and PAG and in the striatum and PAG by morphine only in estrogen-treated animals. Oprd1 expression in the hypothalamus and PAG was activated by morphine in both estrogen-treated and -nontreated animals. The Oprm1 and Oprk1 gene response to morphine might depend on estrogen, whereas the Oprd1 gene response to morphine might not depend on estrogen, supporting the hypothesis of a functional role for ovarian hormones in opioid receptor-mediated functional adaptations in the female brain. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 19% |
Professor > Associate Professor | 2 | 13% |
Professor | 2 | 13% |
Researcher | 2 | 13% |
Student > Doctoral Student | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 31% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Neuroscience | 2 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 2 | 13% |
Unknown | 7 | 44% |