Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

RT @EpiEllie: If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying var…

If you’re gonna ignore time-varying variables, then sure more rounds of panel data won’t help much🤷🏼‍♀️ But time-varying variables are both *important* & *controllable*. So, nope, sorry, more time points *is* better 🕐🕑🕒🕓🕔🕕🕖🕗🕘🕙🕚 Our paper here👉🏼 htt

@omaclaren @NoahHaber @jon_y_huang @PWGTennant @pablogerbas I’m not sure that I agree with the “problem” slide you show there, but the “solutions” side is unarguable. We’ve written about the problem of choosing intervals that are too large: https://t.co/

RT @kaz_yos: https://t.co/dXw9WXnqPd "Bias that arises from interval measurement designs highlights the need for planning in the design of…

RT @kaz_yos: https://t.co/dXw9WXnqPd "Bias that arises from interval measurement designs highlights the need for planning in the design of…

RT @kaz_yos: https://t.co/dXw9WXnqPd "Bias that arises from interval measurement designs highlights the need for planning in the design of…

https://t.co/dXw9WXnqPd "Bias that arises from interval measurement designs highlights the need for planning in the design of randomized trials for collection of time-varying covariate data. This may come from more frequent in-person measurement or externa

RT @EpiEllie: Something that doesn’t get a lot of attention: how frequently do we need to measure our data! This tweetorial about our paper…

Something that doesn’t get a lot of attention: how frequently do we need to measure our data! This tweetorial about our paper explains 👇🏼

Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study | Trials | Full Text https://t.co/dXw9WXnqPd

RT @EpiEllie: @jd_wilko All the time. Here’s one of our recent ones. Plus I have one specifically related to controlled direct effects comi…

@jd_wilko All the time. Here’s one of our recent ones. Plus I have one specifically related to controlled direct effects coming out soon. https://t.co/HsLuuVDTuV

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @DeptPopMed: Check out this excellent #tweetorial by @EpiEllie, co-author on @DeptPopMed Assistant Professor @JessGeraldYoung's new pape…

RT @DeptPopMed: Check out this excellent #tweetorial by @EpiEllie, co-author on @DeptPopMed Assistant Professor @JessGeraldYoung's new pape…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

Check out this excellent #tweetorial by @EpiEllie, co-author on @DeptPopMed Assistant Professor @JessGeraldYoung's new paper!

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

Saving to #AbbeysEpiReadingList

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

Sounds great, going straight on my read pile, thanks for the Tweetorial!

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

RT @EpiEllie: Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about…

Good morning, #epitwitter! I’m a co-author on @JessGeraldYoung’s new paper out now in Trials & I want to tell you all about it! Do you use longitudinal data? Are your measurements often enough? Do you know what “often enough” is? Time for a #tweetor

RT @DeptPopMed: According to a new simulation study in @BioMedCentral #Trials led by @JessGeraldYoung, bias that arises from interval measu…

According to a new simulation study in @BioMedCentral #Trials led by @JessGeraldYoung, bias that arises from interval measurement designs highlights the need for planning in the design of randomized trials for collection of time-varying covariate data. htt

@Sameera_Nayak @SaloniDev But, with 20 years between follow-up visits, you’re going to have a hard time sufficiently controlling for confounding. For some intuition on that (albeit in the RCT setting), see our new paper here 👇🏼 https://t.co/HsLuuVmiDn

RT @cochranemthds: Interval-cohort designs & bias in the estimation of per-protocol effects - simulation study in #Trialsjournal from Jessi…

Interval-cohort designs & bias in the estimation of per-protocol effects - simulation study in #Trialsjournal from Jessica G. Young, Rajet Vatsa, Eleanor J. Murray & Miguel A. Hernán: https://t.co/ymvALDp4Kf @MedicalEvidence

New Article! "Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study." Co authored by @PROMoTeR_DPM collaborator @JessicaGYoung1 is published in #Trials @BioMedCentral https://t.co/YszTSPj0Oh https://t.co/LLxY0NqxhK

RT @kaz_yos: Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study. - PubMed - NCBI https://t.co/n…

Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study. - PubMed - NCBI https://t.co/nhPYYjb8Ed

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: Stay tuned for a tweetorial on our new paper! In the meantime, here’s the link 👇🏼 https://t.co/qdZOpcmNaa

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: Stay tuned for a tweetorial on our new paper! In the meantime, here’s the link 👇🏼 https://t.co/qdZOpcmNaa

RT @EpiEllie: Stay tuned for a tweetorial on our new paper! In the meantime, here’s the link 👇🏼 https://t.co/qdZOpcmNaa

Stay tuned for a tweetorial on our new paper! In the meantime, here’s the link 👇🏼

One for Rheum EPI Journal Club? @dr_rachelblack @LesterSue1 @samwhittle

Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study. https://t.co/7PKA2LbMTf

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

Interval-cohort designs and bias in the estimation of per-protocol effects: a simulation study https://t.co/GWvuApb4L7

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

Add to #AbbeysEpiReadingList

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

Can we please stop calling RCTs a 'gold' standard. Can't recall a single recent #Melanoma RCT that was golden- they all had unequal arms, tweaked inclusions, blinding just to prevent people from leaving. Obviously, my concept of gold might just be wrong 🤔#

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

In my talk today at the #OARSI #SBR2019 South Atlantic Forum on OA, on metholdogical/analytic challenges in RCTs, I noted that the ITT/per-protocol/as-treated question is one that is increasingly getting attention in the literature, and look! A new study f

RT @EpiEllie: How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new p…

How often should you collect data in your randomized trial if you want to estimate a per-protocol effect? Check out our new paper to find out! @JessicaGYoung1 @_MiguelHernan https://t.co/HsLuuVDTuV