| Title |
Chronic hepatitis E virus infection after living donor liver transplantation via blood transfusion: a case report
|
|---|---|
| Published in |
Surgical Case Reports, April 2016
|
| DOI | 10.1186/s40792-016-0159-0 |
| Pubmed ID | |
| Authors |
Takeshi Kurihara, Tomoharu Yoshizumi, Shinji Itoh, Norifumi Harimoto, Noboru Harada, Toru Ikegami, Yuki Inagaki, Yukio Oshiro, Nobuhiro Ohkohchi, Hiroaki Okamoto, Yoshihiko Maehara |
| Abstract |
Although it occurs worldwide, hepatitis E virus (HEV) infection in developed countries is generally foodborne. HEV infection is subclinical in most individuals. Although fulminant liver failure may occur, progression to chronic hepatitis is rare. This study describes a 41-year-old man with liver cirrhosis caused by non-alcoholic steatohepatitis and hepatocellular carcinoma within the Milan criteria. His liver function was classified as Child-Pugh grade C. Living donor liver transplantation (LDLT) was performed, and he was discharged from the hospital on postoperative day (POD) 22. However, his alanine aminotransferase concentration began to increase on POD 60 and HEV infection was detected on POD 81. Retrospective assessments of stored blood samples showed that this patient became positive for HEV RNA on POD 3. The liver donor was negative for anti-HEV antibodies and HEV RNA. However, the platelet concentrate transfused into the liver recipient the day after LDLT was positive for HEV RNA. The patient remained positive for HEV infection for 10 months. Treatment with 800 mg/day ribavirin for 20 weeks reduced HEV RNA to an undetectable level. In conclusion, this report describes a patient infected with HEV through a blood transfusion after LDLT, who progressed to chronic hepatitis probably due to his immunosuppressed state and was treated well with ribavirin therapy. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 18% |
| Student > Doctoral Student | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Bachelor | 3 | 14% |
| Student > Master | 3 | 14% |
| Other | 3 | 14% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 36% |
| Immunology and Microbiology | 4 | 18% |
| Psychology | 2 | 9% |
| Nursing and Health Professions | 1 | 5% |
| Veterinary Science and Veterinary Medicine | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 5 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2016.
All research outputs
#19,026,282
of 24,230,934 outputs
Outputs from Surgical Case Reports
#165
of 519 outputs
Outputs of similar age
#211,972
of 305,290 outputs
Outputs of similar age from Surgical Case Reports
#5
of 10 outputs
Altmetric has tracked 24,230,934 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 519 research outputs from this source. They receive a mean Attention Score of 1.0. This one has gotten more attention than average, scoring higher than 64% of its peers.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.