| Title |
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens
|
|---|---|
| Published in |
Molecular and Cellular Pediatrics, March 2016
|
| DOI | 10.1186/s40348-016-0041-y |
| Pubmed ID | |
| Authors |
Nathalie E. Zeitouni, Sucheera Chotikatum, Maren von Köckritz-Blickwede, Hassan Y. Naim |
| Abstract |
The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted by increasing local blood flow to overcome diminished oxygenation and avoid hypoxic stress. However, studies have shown that the physiological oxygen concentrations in several tissues are much lower than atmospheric (normoxic) conditions, and the oxygen supply is finely regulated in individual cell types. The gastrointestinal tract has been described to subsist in a state of physiologically low oxygen level and is thus depicted as a tissue in the state of constant low-grade inflammation. The intestinal epithelial cell layer plays a vital role in the immune response to inflammation and infections that occur within the intestinal tissue and is involved in many of the adaptation responses to hypoxic stress. This is especially relevant in the context of inflammatory disorders, such as inflammatory bowel disease (IBD). Therefore, this review aims to describe the intestinal epithelial cellular response to hypoxia and the consequences for host interactions with invading gastrointestinal bacterial pathogens. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Italy | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | <1% |
| Unknown | 157 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 29% |
| Student > Master | 20 | 13% |
| Researcher | 19 | 12% |
| Student > Bachelor | 19 | 12% |
| Professor | 9 | 6% |
| Other | 21 | 13% |
| Unknown | 24 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 22% |
| Biochemistry, Genetics and Molecular Biology | 31 | 20% |
| Medicine and Dentistry | 18 | 11% |
| Immunology and Microbiology | 17 | 11% |
| Engineering | 6 | 4% |
| Other | 24 | 15% |
| Unknown | 28 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2020.
All research outputs
#13,228,333
of 22,858,915 outputs
Outputs from Molecular and Cellular Pediatrics
#32
of 98 outputs
Outputs of similar age
#142,090
of 300,114 outputs
Outputs of similar age from Molecular and Cellular Pediatrics
#6
of 11 outputs
Altmetric has tracked 22,858,915 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 98 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 64% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.