Title |
The role of epigenetics in idiopathic male infertility
|
---|---|
Published in |
Journal of Assisted Reproduction and Genetics, March 2016
|
DOI | 10.1007/s10815-016-0682-8 |
Pubmed ID | |
Authors |
Sezgin Gunes, Mehmet Alper Arslan, Gulgez Neslihan Taskurt Hekim, Ramazan Asci |
Abstract |
Infertility is a complex disorder with multiple genetic and environmental causes. Although some specific mutations have been identified, other factors responsible for sperm defects remain largely unknown. Despite considerable efforts to identify the pathophysiology of the disease, we cannot explain the underlying mechanisms of approximately half of infertility cases. This study reviews current data on epigenetic regulation and idiopathic male infertility. Recent data have shown an association between epigenetic modifications and idiopathic infertility. In this regard, epigenetics has emerged as one of the promising research areas in understanding male infertility. Many studies have indicated that epigenetic modifications, including DNA methylation in imprinted and developmental genes, histone tail modifications and short non-coding RNAs in spermatozoa may have a role in idiopathic male infertility. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 25% |
Spain | 1 | 25% |
France | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 2 | 1% |
Unknown | 158 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 29 | 18% |
Student > Ph. D. Student | 25 | 16% |
Researcher | 22 | 14% |
Student > Master | 19 | 12% |
Student > Bachelor | 17 | 11% |
Other | 22 | 14% |
Unknown | 26 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 57 | 36% |
Agricultural and Biological Sciences | 33 | 21% |
Medicine and Dentistry | 23 | 14% |
Nursing and Health Professions | 4 | 3% |
Chemistry | 3 | 2% |
Other | 6 | 4% |
Unknown | 34 | 21% |