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The safety and efficacy of combined autologous concentrated bone marrow grafting and low-intensity pulsed ultrasound in the treatment of osteonecrosis of the femoral head

Overview of attention for article published in European Journal of Orthopaedic Surgery & Traumatology, February 2016
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Title
The safety and efficacy of combined autologous concentrated bone marrow grafting and low-intensity pulsed ultrasound in the treatment of osteonecrosis of the femoral head
Published in
European Journal of Orthopaedic Surgery & Traumatology, February 2016
DOI 10.1007/s00590-016-1752-4
Pubmed ID
Authors

Hajime Mishima, Hisashi Sugaya, Tomokazu Yoshioka, Katsuya Aoto, Hiroshi Wada, Hiroshi Akaogi, Naoyuki Ochiai

Abstract

Osteonecrosis of the femoral head (ONFH) is commonly treated with total hip arthroplasty; however, the disadvantages of this form of treatment, especially in young patients, include the need for revision arthroplasty. Here we describe a novel, combined approach to the treatment of ONFH based on autologous concentrated bone marrow grafting and low-intensity pulsed ultrasound (LIPUS). The 7 male and 7 female patients (mean age: 40 years; 22 hips) underwent autologous concentrated bone marrow grafting followed by 6 months of continuous LIPUS. The mean follow-up period was 26 months. We evaluated site-specific bacterial infection of the grafted bone marrow concentrate microbiologically and site-specific cancer by magnetic resonance imaging 24 months after grafting. All patients were assessed using the visual analogue scale (VAS) for pain and the Japanese Orthopedic Association (JOA) hip score. Clinical and plain radiographic evaluations were performed before grafting and at the most recent follow-up. Computed tomography (CT) scans were obtained before and 12 months after grafting. None of the grafted bone marrow concentrates were infected, and none of the patients developed a tumor at the treatment site. The VAS and JOA scores improved in all patients. Collapse progressed in 8 of the 22 hips, but none required total hip arthroplasty. The mean volume of new bone formation 12 months post-grafting as seen on CT was 1256 mm(3). New bone formation was observed in all patients. Our study demonstrates the safety and efficacy of autologous concentrated bone marrow grafting and LIPUS as a joint-preserving procedure for patients with ONFH.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Student > Bachelor 2 25%
Other 1 13%
Researcher 1 13%
Unspecified 1 13%
Other 0 0%
Readers by discipline Count As %
Nursing and Health Professions 3 38%
Medicine and Dentistry 3 38%
Unspecified 1 13%
Engineering 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2016.
All research outputs
#6,331,397
of 7,325,869 outputs
Outputs from European Journal of Orthopaedic Surgery & Traumatology
#174
of 475 outputs
Outputs of similar age
#238,099
of 282,583 outputs
Outputs of similar age from European Journal of Orthopaedic Surgery & Traumatology
#3
of 21 outputs
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