| Title |
Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study
|
|---|---|
| Published in |
Journal of the Egyptian Public Health Association, January 2019
|
| DOI | 10.1186/s42506-018-0005-2 |
| Pubmed ID | |
| Authors |
Samar Abd ElHafeez, Reem Hegazy, Yasmine Naga, Iman Wahdan, Sunny Sallam |
| Abstract |
Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided among chronic kidney disease (CKD) patients. Till now, limited data are available on NSAID use in Egypt, and we aimed to study the prevalence and pattern of NSAID use among CKD patients. A cross-sectional study was done among 350 CKD adult patients presented to the Main Alexandria University Hospital. Those with end-stage renal disease and diagnosed with acute renal injury and pregnant women were excluded. Demographic and clinical data were collected by interviewing eligible patients. Data about the pattern, history of drug-drug interactions, and knowledge about the NSAID side effects were also gathered. Of the enrolled patients, 57.1% were hypertensive, 46% were diabetics, 28% had osteoarthritis, and 18.3% had cardiovascular disease. CKD stages were 3.7%, 40.3%, and 56% in stages 2, 3, and 4, respectively. Almost two thirds (65.7%) were NSAID users. Among them, 82.6% were regular users. Headache was the most reported (68.7%) reason of use. The use of drugs which may have drug-drug interaction with the NSAIDs (as diuretics or renin-angiotensin-aldosterone system inhibitors) was reported in 36%. In multiple logistic regression, the odds of NSAID use decreased by 4% (odds ratio (OR) = 0.96, 95% confidence interval (CI) 0.93-0.99, p = 0.01) for every year increase in the patient's age and decreased by 3% (OR = 0.97, 95% CI 0.95-0.99, p = 0.01) for every 1 ml/min/1.73 m2 increase in glomerular filtration rate. Despite the hazards of NSAID use on the kidney, still high proportion of CKD patients are using them for a long period and they are simultaneously using other drugs with possible drug-drug interactions. This study provided important information that would decrease the gap in knowledge about the use of NSAID in Egypt. It is recommended that NSAIDs should be used with caution among CKD patients and patients should be advised about its adverse health consequences. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 73 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 18% |
| Researcher | 11 | 15% |
| Student > Ph. D. Student | 9 | 12% |
| Student > Postgraduate | 7 | 10% |
| Student > Doctoral Student | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 20 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Nursing and Health Professions | 5 | 7% |
| Psychology | 2 | 3% |
| Other | 9 | 12% |
| Unknown | 25 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2019.
All research outputs
#22,767,715
of 25,385,509 outputs
Outputs from Journal of the Egyptian Public Health Association
#133
of 162 outputs
Outputs of similar age
#386,030
of 446,949 outputs
Outputs of similar age from Journal of the Egyptian Public Health Association
#5
of 7 outputs
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So far Altmetric has tracked 162 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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