Title |
Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer’s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study
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Published in |
The Journal of Prevention of Alzheimer's Disease, October 2018
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DOI | 10.14283/jpad.2018.41 |
Pubmed ID | |
Authors |
V. Pérez-Grijalba, J. Romero, Pedro Pesini, L. Sarasa, I. Monleón, I. San-José, J. Arbizu, P. Martínez-Lage, J. Munuera, A. Ruiz, L. Tárraga, M. Boada, M. Sarasa |
Abstract |
Easily accessible biomarkers are needed for the early identification of individuals at risk of developing Alzheimer's disease (AD) in large population screening strategies. This study evaluated the potential of plasma β-amyloid (Aβ) biomarkers in identifying early stages of AD and predicting cognitive decline over the following two years. Total plasma Aβ42/40 ratio (TP42/40) was determined in 83 cognitively normal individuals (CN) and 145 subjects with amnestic mild cognitive impairment (a-MCI) stratified by an FDG-PET AD-risk pattern. Significant lower TP42/40 ratio was found in a-MCI patients compared to CN. Moreover, a-MCIs with a high-risk FDG-PET pattern for AD showed even lower plasma ratio levels. Low TP42/40 at baseline increased the risk of progression to dementia by 70%. Furthermore, TP42/40 was inversely associated with neocortical amyloid deposition (measured with PiB-PET) and was concordant with the AD biomarker profile in cerebrospinal fluid (CSF). TP42/40 demonstrated value in the identification of individuals suffering a-MCI, in the prediction of progression to dementia, and in the detection of underlying AD pathology revealed by FDG-PET, Amyloid-PET and CSF biomarkers, being, thus, consistently associated with all the well-established indicators of AD. |
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Geographical breakdown
Country | Count | As % |
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France | 3 | 33% |
United States | 2 | 22% |
United Kingdom | 1 | 11% |
Unknown | 3 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 78% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 100 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 13% |
Student > Bachelor | 10 | 10% |
Student > Ph. D. Student | 8 | 8% |
Other | 4 | 4% |
Unspecified | 3 | 3% |
Other | 13 | 13% |
Unknown | 49 | 49% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 12% |
Neuroscience | 11 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 5% |
Agricultural and Biological Sciences | 4 | 4% |
Chemistry | 3 | 3% |
Other | 16 | 16% |
Unknown | 49 | 49% |