Title |
Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage
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Published in |
SpringerPlus, July 2015
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DOI | 10.1186/s40064-015-1126-0 |
Pubmed ID | |
Authors |
James A Feix, C Andrew Peery, Tong J Gan, David S Warner, Michael L James, Ali Zomorodi, David L McDonagh |
Abstract |
Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited. Associations between resuscitation with hydroxyethyl starch and risk of repeat craniotomy for hematoma evacuation were examined. Using a retrospective cohort of neurosurgical patients at Duke University Medical Center between March 2005 and March 2012, patient characteristics were compared between those who developed post-craniotomy hemorrhage and those who did not. A total of 4,109 craniotomy procedures were analyzed with 61 patients having repeat craniotomy for post-operative hemorrhage (1.5%). The rate of reoperation in the group receiving 6% High Molecular Weight Hydroxyethyl Starch (Hextend(®)) was 2.6 vs. 1.3% for patients that did not receive hetastarch (P = 0.13). The reoperation rate for those receiving 6% hydroxyethyl Starch 130/0.4 (Voluven(®)) was 1.4 vs. 1.6% in patients not receiving Voluven (P = 0.85). In this retrospective cohort, intra-operative hydroxyethyl starch was not associated with an increased risk of post-craniotomy hemorrhage. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 2 | 33% |
Other | 2 | 33% |
Student > Bachelor | 1 | 17% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 50% |
Agricultural and Biological Sciences | 1 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
Unknown | 1 | 17% |