Title |
Enhancement of mechanical strength and in vivo cytocompatibility of porous β-tricalcium phosphate ceramics by gelatin coating
|
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Published in |
International Journal of Implant Dentistry, February 2016
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DOI | 10.1186/s40729-016-0037-3 |
Pubmed ID | |
Authors |
Toshitake Furusawa, Tsutomu Minatoya, Toshimitsu Okudera, Yasuo Sakai, Tomohiro Sato, Yuta Matsushima, Hidero Unuma |
Abstract |
In an attempt to prepare scaffolds with porosity and compressive strength as high as possible, we prepared porous β-tricalcium phosphate (TCP) scaffolds and coated them with regenerative medicine-grade gelatin. The effects of the gelatin coating on the compressive strength and in vivo osteoblast compatibility were investigated. Porous β-TCP scaffolds were prepared and coated with up to 3 mass% gelatin, and then subjected to thermal cross-linking. The gelatin-coated and uncoated scaffolds were then subjected to compressive strength tests and implantation tests into bone defects of Wistar rats. The compressive strength increased by one order of magnitude from 0.45 MPa for uncoated to 5.1 MPa for gelatin-coated scaffolds. The osteoblast density in the internal space of the scaffold increased by 40 % through gelatin coating. Coating porous bone graft materials with gelatin is a promising measure to enhance both mechanical strength and biomedical efficacy at the same time. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 17% |
Other | 3 | 13% |
Student > Doctoral Student | 3 | 13% |
Researcher | 3 | 13% |
Student > Ph. D. Student | 2 | 8% |
Other | 4 | 17% |
Unknown | 5 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 8 | 33% |
Materials Science | 5 | 21% |
Neuroscience | 1 | 4% |
Chemical Engineering | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 29% |