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Increased body fat is associated with potentiation of blood pressure response to hypoxia in healthy men: relations with insulin and leptin

Overview of attention for article published in Clinical Autonomic Research, January 2016
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Title
Increased body fat is associated with potentiation of blood pressure response to hypoxia in healthy men: relations with insulin and leptin
Published in
Clinical Autonomic Research, January 2016
DOI 10.1007/s10286-015-0338-2
Pubmed ID
Authors

Bartłomiej Paleczny, Agnieszka Siennicka, Maciej Zacharski, Ewa Anita Jankowska, Beata Ponikowska, Piotr Ponikowski

Abstract

Increased peripheral chemosensitivity (PChS) has been proposed as mechanism underlying obesity-related sympathoactivation, with insulin and/or leptin as possible mediators. However, human data on PChS in obesity are scarce. Therefore, we explored this issue in a sample of 41 healthy men aged 30-59 years, divided according to body fat percentage (fat %) into two groups: <25 and ≥25 %. PChS was assessed using transient hypoxia method [respiratory (PChS-MV), heart rate (PChS-HR), and blood pressure (PChS-SBP) responses were calculated]. Baroreflex sensitivity (BRS-Seq) was assessed using sequence method. Fasting plasma insulin and leptin levels were measured. Homeostatic model assessment (HOMA) was used to assess insulin sensitivity/resistance. Individuals with ≥25 % body fat demonstrated increased PChS-SBP (p < 0.01), but unchanged PChS-MV and PChS-HR (both p > 0.4). PChS-SBP was related positively with anthropometric characteristics (e.g. waist circumference, fat %), plasma insulin and HOMA (all p < 0.05), and negatively with BRS-Seq (p = 0.001), but not with plasma leptin (p = 0.27). In healthy men, overweight/obesity is accompanied by augmented blood pressure response from peripheral chemoreceptors, while respiratory and heart rate responses remain unaltered. Hyperinsulinaemia and insulin resistance (but not hyperleptinaemia) are associated with augmented pressure response from chemoreceptors.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 32%
Professor 3 16%
Student > Master 3 16%
Other 2 11%
Unspecified 2 11%
Other 3 16%
Readers by discipline Count As %
Medicine and Dentistry 7 37%
Biochemistry, Genetics and Molecular Biology 3 16%
Unspecified 3 16%
Agricultural and Biological Sciences 2 11%
Sports and Recreations 1 5%
Other 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2016.
All research outputs
#11,373,588
of 12,787,438 outputs
Outputs from Clinical Autonomic Research
#392
of 417 outputs
Outputs of similar age
#272,869
of 332,277 outputs
Outputs of similar age from Clinical Autonomic Research
#12
of 12 outputs
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.