Title |
MicroRNA-503 represses epithelial–mesenchymal transition and inhibits metastasis of osteosarcoma by targeting c-myb
|
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Published in |
Tumor Biology, January 2016
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DOI | 10.1007/s13277-016-4797-4 |
Pubmed ID | |
Authors |
Xinzhen Guo, Jie Zhang, Jianfeng Pang, Sheng He, Guojun Li, Yang Chong, Chao Li, Zhijian Jiao, Shiqian Zhang, Ming Shao |
Abstract |
Deregulated expression of miRNAs contributes to the development of osteosarcoma. Our previous study has showed that miR-503 was downregulated in osteosarcoma tissues. However, the mechanism of the miR-503 in osteosarcoma development still remains largely undefined. In our study, we found that miR-503 overexpression suppressed cell invasion and migration and inhibited epithelial-to-mesenchymal transition (EMT) of MG-63. Furthermore, we identified that c-myb, an oncogene, was a direct target of miR-503. Moreover, overexpression of c-myb could rescue miR-503-suppressed invasion and EMT. The expression of c-myb was upregulated in osteosarcoma cell lines. Therefore, we conclude that high miR-503 expression suppressed osteosarcoma cell mobility and EMT through targeting c-myb, and this may serve as a therapeutic target. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 33% |
Researcher | 3 | 20% |
Student > Postgraduate | 2 | 13% |
Student > Master | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 40% |
Medicine and Dentistry | 3 | 20% |
Agricultural and Biological Sciences | 2 | 13% |
Engineering | 1 | 7% |
Unknown | 3 | 20% |