Title |
Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction
|
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Published in |
Cellular and Molecular Life Sciences, January 2016
|
DOI | 10.1007/s00018-015-2127-4 |
Pubmed ID | |
Authors |
Tatiana Gorojankina |
Abstract |
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning and stem cell maintenance. In spite of intensive study, the mechanisms of Hh signal transduction are not completely understood. Here I review published data and present a novel model of vertebrate Hh signaling suggesting that Smoothened (Smo) functions as a G-protein-coupled receptor in cilia. This is the first model to propose molecular mechanisms for the major steps of Hh signaling, including inhibition of Smo by Patched, Smo activation, and signal transduction from active Smo to Gli transcription factors. It also suggests a novel role for the negative pathway regulators Sufu and PKA in these processes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | <1% |
Unknown | 120 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 17% |
Researcher | 20 | 17% |
Student > Master | 18 | 15% |
Student > Bachelor | 14 | 12% |
Student > Doctoral Student | 7 | 6% |
Other | 22 | 18% |
Unknown | 20 | 17% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 45 | 37% |
Agricultural and Biological Sciences | 31 | 26% |
Medicine and Dentistry | 10 | 8% |
Immunology and Microbiology | 3 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 8 | 7% |
Unknown | 22 | 18% |