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Protein myozap — a late addition to the molecular ensembles of various kinds of adherens junctions

Overview of attention for article published in Cell & Tissue Research, December 2011
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Title
Protein myozap — a late addition to the molecular ensembles of various kinds of adherens junctions
Published in
Cell & Tissue Research, December 2011
DOI 10.1007/s00441-011-1281-8
Pubmed ID
Authors

Steffen Rickelt, Caecilia Kuhn, Stefanie Winter-Simanowski, Ralf Zimbelmann, Norbert Frey, Werner Wilhelm Franke

Abstract

The protein myozap, a polypeptide of 54 kDa, has recently been identified as a component of the cytoplasmic plaques of the composite junctions (areae compositae) in the myocardiac intercalated disks and of the adherens junctions (AJs) in vascular endothelia. Now we report that using very sensitive new antibodies and drastic localization methods, we have also identified this protein as a component of the AJ plaques in simple and complex epithelia, in the adluminal cell layer of the transitional epithelium of the urinary tract and in certain cell layers of diverse stratified epithelia, including gingiva, tongue, pharynx and esophagus, cervix, vagina and epidermis. Myozap has not been identified in desmosomal and tight junction plaques. We have also detected protein myozap in AJ structures of carcinomas. The discovery of a novel major protein in AJ plaques now calls for re-examinations of molecular interactions in AJ formation and maintenance and also offers a new marker for diagnostic immunocytochemistry. We also discuss the need for progressive unravelling, extractive treatments and buffer rinses of sections and cultured cells to reveal obscured or masked antigens, before definitive negative conclusions in immunohistochemistry can be made.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 33%
Researcher 2 33%
Lecturer > Senior Lecturer 1 17%
Unspecified 1 17%
Readers by discipline Count As %
Medicine and Dentistry 3 50%
Agricultural and Biological Sciences 2 33%
Unspecified 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2011.
All research outputs
#8,456,599
of 9,696,449 outputs
Outputs from Cell & Tissue Research
#921
of 1,113 outputs
Outputs of similar age
#217,359
of 257,102 outputs
Outputs of similar age from Cell & Tissue Research
#22
of 24 outputs
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So far Altmetric has tracked 1,113 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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