| Title |
Tight junction structure, function, and assessment in the critically ill: a systematic review
|
|---|---|
| Published in |
Intensive Care Medicine Experimental, September 2018
|
| DOI | 10.1186/s40635-018-0203-4 |
| Pubmed ID | |
| Authors |
David Vermette, Pamela Hu, Michael F Canarie, Melissa Funaro, Janis Glover, Richard W Pierce |
| Abstract |
Epithelial and endothelial barrier integrity, essential for homeostasis, is maintained by cellular boarder structures known as tight junctions (TJs). In critical illness, TJs may become disrupted, resulting in barrier dysfunction manifesting as capillary leak, pulmonary edema, gut bacterial translocation, and multiple organ failure. We aim to provide a clinically focused overview of TJ structure and function and systematically review and analyze all studies assessing markers of endothelial and epithelial TJ breakdown correlated with clinical outcomes in critically ill humans. We systematically searched MEDLINE, EMBASE, and PubMed. Additional articles were identified by targeted searches. We included studies that looked at the relationship between biomarkers of endothelial or epithelial TJ structure or function and critical illness. Results were qualitatively analyzed due to sample size and heterogeneity. A total of 5297 abstracts met search criteria, of which 150 articles met requirements for full text review. Of these, 30 studies met inclusion criteria. Fifteen of the 30 reports investigated proteins of endothelial tight junctions and 15 investigated epithelial TJ markers, exclusively in the gastrointestinal epithelium. No studies investigated TJ-derived proteins in primary cardiac or pulmonary pathology. TJ integrity is essential for homeostasis. We identified multiple studies that indicate TJs are disrupted by critical illness. These studies highlight the significance of barrier disruption across many critical disease states and correlate TJ-associated markers to clinically relevant outcomes. Further study on the role of multiple tissue-specific claudins, particularly in the setting of respiratory or cardiac failure, may lead to diagnostic and therapeutic advances. This systematic review is registered in the PROSPERO database: CRD42017074546 . |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 17% |
| Student > Master | 22 | 14% |
| Researcher | 17 | 11% |
| Student > Ph. D. Student | 17 | 11% |
| Student > Doctoral Student | 10 | 6% |
| Other | 19 | 12% |
| Unknown | 46 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 16% |
| Biochemistry, Genetics and Molecular Biology | 25 | 16% |
| Agricultural and Biological Sciences | 17 | 11% |
| Immunology and Microbiology | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 27 | 17% |
| Unknown | 49 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2018.
All research outputs
#18,650,639
of 23,105,443 outputs
Outputs from Intensive Care Medicine Experimental
#329
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Outputs of similar age
#261,436
of 341,556 outputs
Outputs of similar age from Intensive Care Medicine Experimental
#10
of 18 outputs
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