Title |
Transplantation of mesenchymal stem cells improves type 1 diabetes mellitus
|
---|---|
Published in |
Cell and Tissue Research, December 2015
|
DOI | 10.1007/s00441-015-2330-5 |
Pubmed ID | |
Authors |
Lisha Li, Furong Li, Feng Gao, Yali Yang, Yuanyuan Liu, Pingping Guo, Yulin Li |
Abstract |
Bone-marrow-derived stem cells can regenerate pancreatic tissue in a model of type 1 diabetes mellitus. Mesenchymal stem cells (MSCs) form the main part of bone marrow. We show that the intrapancreatic transplantation of MSCs elevates serum insulin and C-peptide, while decreasing blood glucose. MSCs engrafted into the damaged rat pancreas become distributed into the blood vessels, acini, ducts, and islets. Renascent islets, islet-like clusters, and a small number of MSCs expressing insulin protein have been observed in the pancreas of diabetic rats. Intrapancreatic transplantation of MSCs triggers a series of molecular and cellular events, including differentiation towards the pancreas directly and the provision of a niche to start endogenous pancreatic regeneration, which ameliorates hypoinsulinemia and hyperglycemia caused by streptozotocin. These data establish the many roles of MSCs in the restoration of the function of an injured organ. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 48 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 20% |
Student > Master | 8 | 16% |
Researcher | 7 | 14% |
Student > Ph. D. Student | 6 | 12% |
Other | 3 | 6% |
Other | 7 | 14% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 12 | 24% |
Agricultural and Biological Sciences | 10 | 20% |
Medicine and Dentistry | 7 | 14% |
Veterinary Science and Veterinary Medicine | 3 | 6% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 10% |
Unknown | 11 | 22% |