Title |
The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization
|
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Published in |
Tumor Biology, December 2015
|
DOI | 10.1007/s13277-015-4451-6 |
Pubmed ID | |
Authors |
Changming Wang, Zunqi Hu, Zhenxin Zhu, Xin Zhang, Ziran Wei, Yu Zhang, Dali Hu, Qingping Cai |
Abstract |
Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice. |
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