| Title |
Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells
|
|---|---|
| Published in |
Intensive Care Medicine Experimental, October 2015
|
| DOI | 10.1186/s40635-015-0066-x |
| Pubmed ID | |
| Authors |
Monique Michels, Amanda V. Steckert, João Quevedo, Tatiana Barichello, Felipe Dal-Pizzol |
| Abstract |
Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the blood-brain barrier, secretion of inflammatory cytokines, and these alterations could induce neuronal dysfunction. Furthermore, blood-borne leukocytes can also reach the brain and participate in inflammatory response. Mechanisms involved in sepsis-associated brain dysfunction were revised here, focusing in neuroinflammation and involvement of blood-borne leukocytes and glial cells in this process. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 16% |
| Student > Master | 9 | 13% |
| Researcher | 7 | 10% |
| Student > Doctoral Student | 6 | 9% |
| Other | 6 | 9% |
| Other | 11 | 16% |
| Unknown | 19 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 20% |
| Neuroscience | 13 | 19% |
| Immunology and Microbiology | 6 | 9% |
| Agricultural and Biological Sciences | 6 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 21 | 30% |