| Title |
Benzoxazole derivatives: design, synthesis and biological evaluation
|
|---|---|
| Published in |
Chemistry Central Journal, August 2018
|
| DOI | 10.1186/s13065-018-0459-5 |
| Pubmed ID | |
| Authors |
Saloni Kakkar, Sumit Tahlan, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani, Syed Adnan Ali Shah, Balasubramanian Narasimhan |
| Abstract |
A new series of benzoxazole analogues was synthesized and checked for their in vitro antibacterial, antifungal and anticancer activities. The synthesized benzoxazole compounds were confirmed by IR, 1H/13C-NMR, mass and screened for their in vitro antimicrobial activity against Gram-positive bacterium: Bacillus subtilis, four Gram-negative bacteria: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi and two fungal strains: Candida albicans and Aspergillus niger using tube dilution technique and minimum inhibitory concentration (MIC) was noted in µM and compared to ofloxacin and fluconazole. Human colorectal carcinoma (HCT116) cancer cell line was used for the determination of in vitro anticancer activity (IC50 value) by Sulforhodamine B assay using 5-fluorouracil as standard drug. The performed study indicated that the compounds 1, 10, 13, 16, 19, 20 and 24 had highest antimicrobial activity with MIC values comparable to ofloxacin and fluconazole and compounds 4, 6, 25 and 26 had best anticancer activity in comparison to 5-fluorouracil. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 101 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 12% |
| Researcher | 9 | 9% |
| Student > Bachelor | 9 | 9% |
| Student > Master | 9 | 9% |
| Student > Doctoral Student | 5 | 5% |
| Other | 11 | 11% |
| Unknown | 46 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 30 | 30% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Medicine and Dentistry | 2 | 2% |
| Immunology and Microbiology | 1 | <1% |
| Other | 3 | 3% |
| Unknown | 52 | 51% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2018.
All research outputs
#21,158,537
of 25,988,468 outputs
Outputs from Chemistry Central Journal
#255
of 410 outputs
Outputs of similar age
#268,600
of 344,521 outputs
Outputs of similar age from Chemistry Central Journal
#1
of 1 outputs
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So far Altmetric has tracked 410 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them