| Title |
Remodeling an infarcted heart: novel hybrid treatment with transmyocardial revascularization and stem cell therapy
|
|---|---|
| Published in |
SpringerPlus, June 2016
|
| DOI | 10.1186/s40064-016-2355-6 |
| Pubmed ID | |
| Authors |
Jessika Iwanski, Raymond K. Wong, Douglas F. Larson, Alice S. Ferng, Raymond B. Runyan, Steven Goldstein, Zain Khalpey |
| Abstract |
Transmyocardial revascularization (TMR) has emerged as an additional therapeutic option for patients suffering from diffuse coronary artery disease (CAD), providing immediate angina relief. Recent studies indicate that the volume of surgical cases being performed with TMR have been steadily rising, utilizing TMR as an adjunctive therapy. Therefore the purpose of this review is to provide an up-to-date appreciation of the current state of TMR and its future developmental directions on CAD treatment. The current potential of this therapy focuses on the implementation of stem cells, in order to create a synergistic angiogenic effect while increasing myocardial repair and regeneration. Although TMR procedures provide increased vascularization within the myocardium, patients suffering from ischemic cardiomyopathy may not benefit from angiogenesis alone. Therefore, the goal of introducing stem cells is to restore the functional state of a failing heart by providing these cells with a favorable microenvironment that will enhance stem cell engraftment. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 9 | 26% |
| Student > Bachelor | 6 | 18% |
| Professor | 4 | 12% |
| Student > Ph. D. Student | 4 | 12% |
| Researcher | 3 | 9% |
| Other | 5 | 15% |
| Unknown | 3 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 32% |
| Nursing and Health Professions | 4 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Computer Science | 2 | 6% |
| Agricultural and Biological Sciences | 2 | 6% |
| Other | 6 | 18% |
| Unknown | 7 | 21% |