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A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms

Overview of attention for article published in Digestive Diseases & Sciences, August 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 2,566)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
78 news outlets
twitter
23 tweeters
facebook
6 Facebook pages
video
6 video uploaders

Citations

dimensions_citation
46 Dimensions

Readers on

mendeley
106 Mendeley
Title
A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms
Published in
Digestive Diseases & Sciences, August 2015
DOI 10.1007/s10620-015-3858-7
Pubmed ID
Authors

Brooks D. Cash, Michael S. Epstein, Syed M. Shah

Abstract

Peppermint oil (PO) has shown promise as an IBS therapy, but previous trials have demonstrated variable efficacy and tolerability results. To evaluate the efficacy and tolerability of a novel formulation of PO designed for sustained release in the small intestine in patients with IBS-M and IBS-D. This is a 4-week, randomized, double-blind, placebo-controlled clinical trial of PO or identical placebo 3 times daily in patients fulfilling Rome III criteria for IBS-M or IBS-D. The primary endpoint was the change from baseline in the Total IBS Symptom Score (TISS) after 4 weeks of treatment. Seventy-two patients (mean age 40.7 years, 75 % female, 77.8 % white) were randomized to PO (n = 35) or placebo (n = 37). At 4 weeks, PO was associated with a 40 % reduction in the TISS from baseline (mean change -1.16, SD ± 0.807), superior to the 24.3 % decrease (mean change -0.70, SD ± 0.737) observed with placebo (P = 0.0246). The decrease in the TISS of 19.6 % (mean change -0.55, SD ± 0.613) in the PO group at 24 h was also significantly larger than placebo (-10.3 %, mean change -0.27, SD ± 0.342) (P = 0.0092). At trial completion, patients in the PO group experienced greater improvement in multiple individual gastrointestinal symptoms as well as in severe or unbearable symptoms, compared to placebo. PO was well tolerated with few adverse events. A novel PO formulation designed for sustained release in the small intestine is a safe, effective treatment capable of providing rapid relief of IBS symptoms.

Twitter Demographics

The data shown below were collected from the profiles of 23 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 105 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 47 44%
Unspecified 14 13%
Researcher 9 8%
Other 9 8%
Student > Master 8 8%
Other 19 18%
Readers by discipline Count As %
Medicine and Dentistry 39 37%
Nursing and Health Professions 18 17%
Unspecified 16 15%
Pharmacology, Toxicology and Pharmaceutical Science 9 8%
Biochemistry, Genetics and Molecular Biology 7 7%
Other 17 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 610. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2019.
All research outputs
#10,441
of 13,218,768 outputs
Outputs from Digestive Diseases & Sciences
#1
of 2,566 outputs
Outputs of similar age
#225
of 238,543 outputs
Outputs of similar age from Digestive Diseases & Sciences
#1
of 46 outputs
Altmetric has tracked 13,218,768 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,566 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,543 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.