Title |
The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis
|
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Published in |
Cell Regeneration, August 2015
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DOI | 10.1186/s13619-015-0019-6 |
Pubmed ID | |
Authors |
S. T. Ngo, F. J. Steyn |
Abstract |
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that is characterized by the selective degeneration of upper motor neurons and lower spinal motor neurons, resulting in the progressive paralysis of all voluntary muscles. Approximately 10 % of ALS cases are linked to known genetic mutations, with the remaining 90 % of cases being sporadic. While the primary pathology in ALS is the selective death of upper and lower motor neurons, numerous studies indicate that an imbalance in whole body and/or cellular metabolism influences the rate of progression of disease. This review summarizes current research surrounding the impact of impaired metabolic physiology in ALS. We extend ideas to consider prospects that lie ahead in terms of how metabolic alterations may impact the selective degeneration of neurons in ALS and how targeting of adenosine triphosphate-sensitive potassium (KATP) channels may represent a promising approach for obtaining neuroprotection in ALS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Comoros | 1 | 25% |
Australia | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Australia | 1 | <1% |
Unknown | 108 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 19% |
Researcher | 17 | 15% |
Student > Bachelor | 10 | 9% |
Student > Master | 10 | 9% |
Student > Doctoral Student | 6 | 5% |
Other | 13 | 12% |
Unknown | 33 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 18 | 16% |
Biochemistry, Genetics and Molecular Biology | 16 | 15% |
Agricultural and Biological Sciences | 15 | 14% |
Medicine and Dentistry | 14 | 13% |
Nursing and Health Professions | 3 | 3% |
Other | 7 | 6% |
Unknown | 37 | 34% |