Title |
WNT Signaling and Colorectal Cancer
|
---|---|
Published in |
Current Colorectal Cancer Reports, February 2017
|
DOI | 10.1007/s11888-017-0354-9 |
Pubmed ID | |
Authors |
Emma M. Schatoff, Benjamin I. Leach, Lukas E. Dow |
Abstract |
The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 300 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 300 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 57 | 19% |
Student > Ph. D. Student | 45 | 15% |
Student > Master | 40 | 13% |
Researcher | 18 | 6% |
Student > Doctoral Student | 13 | 4% |
Other | 26 | 9% |
Unknown | 101 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 103 | 34% |
Medicine and Dentistry | 31 | 10% |
Agricultural and Biological Sciences | 15 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 4% |
Immunology and Microbiology | 10 | 3% |
Other | 20 | 7% |
Unknown | 108 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2022.
All research outputs
#3,416,577
of 25,382,440 outputs
Outputs from Current Colorectal Cancer Reports
#106
of 737 outputs
Outputs of similar age
#60,399
of 324,194 outputs
Outputs of similar age from Current Colorectal Cancer Reports
#3
of 21 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 737 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,194 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.