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Rapid evaluation of the quantity of drugs encapsulated within nanoparticles by high-performance liquid chromatography in a monolithic silica column

Overview of attention for article published in Analytical & Bioanalytical Chemistry, June 2015
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Title
Rapid evaluation of the quantity of drugs encapsulated within nanoparticles by high-performance liquid chromatography in a monolithic silica column
Published in
Analytical & Bioanalytical Chemistry, June 2015
DOI 10.1007/s00216-015-8805-0
Pubmed ID
Authors

Naoki Itoh, Tomofumi Santa, Masaru Kato

Abstract

Drug-containing nanoparticles, the foundation of nanomedicine, provide promise for the safe and effective delivery of drugs to their targets. In this study, we developed a simple method to determine the relative quantities of nanoparticle-encapsulated drugs by HPLC using a commercially available monolithic silica column. Amphotericin B- and irinotecan-containing nanoparticles produced nearly simultaneous elution peaks (~7 min), suggesting that elution was largely driven by hydrodynamic effects and was relatively unaffected by differences in the encapsulated drug. A good correlation was observed between the intensity of the nanoparticle peak and the relative quantity of encapsulated drug. We used our method to characterize the effects of drug quantity and nanoparticle size on drug encapsulation rates within the nanoparticles. Encapsulation increased with increasing quantities of the drug in the preparation solution. This effect was greater for irinotecan than for amphotericin B. Although absolute encapsulation also increased with increasing nanoparticle size, encapsulation efficiency decreased. Thus, the monolith column is suitable for evaluating nanomedicine quality and may be used to evaluate many kinds of nanomaterials. Graphical Abstract Evaluation method of quantity of drug encapsulated within nanoparticles was developed. The method can be applicable for a rapid quality assurance of nanomedicine.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 9%
Unknown 10 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 45%
Researcher 2 18%
Student > Bachelor 1 9%
Other 1 9%
Student > Doctoral Student 1 9%
Other 1 9%
Readers by discipline Count As %
Chemistry 3 27%
Pharmacology, Toxicology and Pharmaceutical Science 2 18%
Agricultural and Biological Sciences 2 18%
Chemical Engineering 1 9%
Unspecified 1 9%
Other 2 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#10,841,676
of 12,230,555 outputs
Outputs from Analytical & Bioanalytical Chemistry
#3,563
of 4,657 outputs
Outputs of similar age
#195,652
of 237,812 outputs
Outputs of similar age from Analytical & Bioanalytical Chemistry
#120
of 311 outputs
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