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Effects of intravenous immunoglobulin therapy on behavior deficits and functions in sepsis model

Overview of attention for article published in Annals of Intensive Care, July 2015
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Title
Effects of intravenous immunoglobulin therapy on behavior deficits and functions in sepsis model
Published in
Annals of Intensive Care, July 2015
DOI 10.1186/s13613-015-0062-z
Pubmed ID
Authors

Perihan Ergin Ozcan, Evren Senturk, Gunseli Orhun, Salih Gumru, Nadir Arican, Nurcan Orhan, Canan Ugur Yılmaz, Mehmet Kaya, Feyza Aricioglu, Figen Esen

Abstract

We aim to demonstrate behavioral alterations in a sepsis model using intravenous (IV) immunoglobulin G (IgG) and immunoglobulins enriched with IgA and IgM (IgGAM). We divided 48 Wistar albino rats into five groups: control group, sham-operated group (only antibiotic treatment), cecal ligation and puncture (CLP) group (CLP plus antibiotic treatment), IgG group (250 mg/kg IV IgG) and IgGAM group (250 mg/kg IV IgGAM). Intravenous immunoglobulins were given 5 min after the CLP procedure. Experimental animals put into three behavioral tasks 10, 30 and 60 days after the surgery; to evaluate the locomotor activity, an open field test was performed, elevated plus maze test was used to measure anxiety levels, and depressive state was assessed by forced swimming test. The effects of therapy which were acquired from the results of these tests were used to estimate the behavioral changes after CLP. The mortality rate of 50% in the septic rats decreased to 30 and 20% with the administration of IgG and IgGAM, respectively. Significant changes on locomotor activity and depressive-like behavior were reported in the sepsis group; on the other hand, the treatment with immunoglobulins reduced the symptoms. Treatment with immunoglobulins attenuated the sepsis-related anxiogenic-like responses. Behavioral alterations returned to normal on day 60 in all groups. Sepsis caused deterioration on behavioral parameters. Immunoglobulin treatments alleviated the symptoms of functional disturbances and caused early reversal of behavioral deficits in septic animals.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Researcher 4 14%
Student > Master 4 14%
Student > Bachelor 3 10%
Professor 3 10%
Other 7 24%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 11 38%
Neuroscience 4 14%
Agricultural and Biological Sciences 4 14%
Computer Science 2 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 2 7%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2015.
All research outputs
#3,819,792
of 5,428,000 outputs
Outputs from Annals of Intensive Care
#217
of 268 outputs
Outputs of similar age
#131,319
of 189,773 outputs
Outputs of similar age from Annals of Intensive Care
#7
of 7 outputs
Altmetric has tracked 5,428,000 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 268 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,773 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
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