Title |
Biotransformation of Steroids and Flavonoids by Cultures of Aspergillus niger
|
---|---|
Published in |
Applied Biochemistry and Biotechnology, May 2015
|
DOI | 10.1007/s12010-015-1619-x |
Pubmed ID | |
Authors |
Igor A. Parshikov, John B. Sutherland |
Abstract |
Steroids are derivatives of the triterpenoid squalene, containing three fused cyclohexane rings and a cyclopentane ring, and flavonoids are derivatives of L-phenylalanine, containing two aromatic rings joined by a three-carbon bridge that may form part of a heterocyclic ring. A great variety of steroids and flavonoids are produced by plants, and many additional steroids are produced by animals or fungi. Because these compounds have many nutritional and pharmaceutical values, and many of them cannot be produced by chemical synthesis, biotechnological processes are being developed that use cultures of Aspergillus niger and other fungi to transform steroids and flavonoids to a variety of metabolites. These biochemical reactions, including hydroxylation, dehydrogenation, O-methylation, demethylation, cleavage of rings, epoxide hydrolysis, double bond reduction, and others, may be used for the production of higher-value compounds. |
X Demographics
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
Unknown | 63 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 17% |
Student > Bachelor | 10 | 16% |
Researcher | 9 | 14% |
Student > Master | 7 | 11% |
Student > Doctoral Student | 3 | 5% |
Other | 9 | 14% |
Unknown | 15 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 14 | 22% |
Biochemistry, Genetics and Molecular Biology | 11 | 17% |
Agricultural and Biological Sciences | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Environmental Science | 2 | 3% |
Other | 6 | 9% |
Unknown | 20 | 31% |