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The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins

Overview of attention for article published in Cell & Tissue Research, July 2015
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Title
The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins
Published in
Cell & Tissue Research, July 2015
DOI 10.1007/s00441-015-2236-2
Pubmed ID
Authors

M. A. Costa, B. M. Fonseca, A. Mendes, J. Braga, N. A. Teixeira, Georgina Correia da Silva

Abstract

The human syncytiotrophoblast (hST) has a major role in the production of important placental hormones. Several molecules regulate hST endocrine function but the role of endocannabinoids in this process is still unknown. Here, we report that the endocannabinoid anandamide (AEA) decreased cAMP levels, impaired human chorionic gonadotropin secretion, placental alkaline phosphatase activity and decreased aromatase mRNA levels and protein expression, through cannabinoid (CB) receptor activation. AEA also downregulated leptin and placental protein 13 transcription, though via a CB receptor-independent mechanism. All this evidence suggests AEA is a novel modulator of hormone synthesis by the syncytiotrophoblast, supporting the importance of the endocannabinoid signalling in placental function.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 10%
Unknown 9 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 40%
Unspecified 3 30%
Other 1 10%
Researcher 1 10%
Professor 1 10%
Other 0 0%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 30%
Unspecified 3 30%
Medicine and Dentistry 2 20%
Biochemistry, Genetics and Molecular Biology 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2016.
All research outputs
#10,839,557
of 12,228,143 outputs
Outputs from Cell & Tissue Research
#1,315
of 1,535 outputs
Outputs of similar age
#196,211
of 237,922 outputs
Outputs of similar age from Cell & Tissue Research
#30
of 41 outputs
Altmetric has tracked 12,228,143 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,535 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,922 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.