| Title |
Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial
|
|---|---|
| Published in |
European Journal of Nutrition, May 2018
|
| DOI | 10.1007/s00394-018-1721-2 |
| Pubmed ID | |
| Authors |
Marc R. Bomhof, Jill A. Parnell, Hena R. Ramay, Pam Crotty, Kevin P. Rioux, Chris S. Probert, Saumya Jayakumar, Maitreyi Raman, Raylene A. Reimer |
| Abstract |
In obesity and diabetes the liver is highly susceptible to abnormal uptake and storage of fat. In certain individuals hepatic steatosis predisposes to the development of non-alcoholic steatohepatitis (NASH), a disease marked by hepatic inflammation and fibrosis. Although the precise pathophysiology of NASH is unknown, it is believed that the gut microbiota-liver axis influences the development of this disease. With few treatment strategies available for NASH, exploration of gut microbiota-targeted interventions is warranted. We investigated the therapeutic potential of a prebiotic supplement to improve histological parameters of NASH. In a placebo-controlled, randomized pilot trial, 14 individuals with liver-biopsy-confirmed NASH [non-alcoholic fatty liver activity score (NAS) ≥ 5] were randomized to receive oligofructose (8 g/day for 12 weeks followed by 16 g/day for 24 weeks) or isocaloric placebo for 9 months. The primary outcome measure was the change in liver biopsy NAS score and the secondary outcomes included changes in body weight, body composition, glucose tolerance, inflammatory markers, and gut microbiota. Independent of weight loss, oligofructose improved liver steatosis relative to placebo and improved overall NAS score (P = 0.016). Bifidobacterium was enhanced by oligofructose, whereas bacteria within Clostridium cluster XI and I were reduced with oligofructose (P < 0.05). There were no adverse side effects that deterred individuals from consuming oligofructose for treatment of this disease. Independent of other lifestyle changes, prebiotic supplementation reduced histologically-confirmed steatosis in patients with NASH. Larger follow-up studies are warranted. This trial was registered at Clinicaltrials.com as NCT03184376. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 14% |
| United States | 1 | 14% |
| Unknown | 5 | 71% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 178 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 12% |
| Student > Bachelor | 19 | 11% |
| Researcher | 17 | 10% |
| Student > Ph. D. Student | 13 | 7% |
| Student > Doctoral Student | 8 | 4% |
| Other | 17 | 10% |
| Unknown | 82 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 13% |
| Nursing and Health Professions | 16 | 9% |
| Biochemistry, Genetics and Molecular Biology | 14 | 8% |
| Agricultural and Biological Sciences | 6 | 3% |
| Immunology and Microbiology | 4 | 2% |
| Other | 18 | 10% |
| Unknown | 96 | 54% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2019.
All research outputs
#13,366,249
of 23,063,209 outputs
Outputs from European Journal of Nutrition
#1,474
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Outputs of similar age
#164,594
of 329,526 outputs
Outputs of similar age from European Journal of Nutrition
#34
of 65 outputs
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