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Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat

Overview of attention for article published in Psychopharmacology, November 2001
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
wikipedia
2 Wikipedia pages

Citations

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7 Dimensions

Readers on

mendeley
7 Mendeley
Title
Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat
Published in
Psychopharmacology, November 2001
DOI 10.1007/s002130100891
Pubmed ID
Authors

Charles D. Cook, Ivy F. Carroll, Patrick M. Beardsley

Abstract

Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serotonin (SERT) transporters in the behavioral effects of cocaine. As such, several groups have developed compounds that exhibit high affinity and selectivity for the DAT. The present investigation examined the cocaine-like discriminative stimulus effects in rats of novel cocaine analogs (RTI 12, 13, 15) and 3-phenyltropane analogs (RTI 111, 112, 113, 114, 117 120, 121, 123, 134 and 152) of which several exhibit high affinity (e.g., <7 nM) and selectivity for the DAT. During dose-effect testing all drugs produced 75-100% cocaine-lever responding. Analyses indicated that the potency of the compounds to produce cocaine-like discriminative stimulus effects was correlated with their affinity for the DAT and the NET but not SERT. Due to the extremely large concentrations (e.g., 10,000-31,024 nM) needed to occupy the NET in vitro, it is doubtful if the doses administered had meaningful NET activity. The selectivity at the DAT, relative to the other transporters, was not indicative of the potency with which these drugs substituted for cocaine. The cocaine-like discriminative stimulus of the RTI compounds tested appear to be mediated by the DAT, however the extent to which the NET is involved remains unclear. Additionally, several of the RTI compounds had properties consistent with those thought desirable in a pharmacotherapeutic for cocaine dependence.

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Slovenia 1 14%
Unknown 6 86%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 29%
Student > Ph. D. Student 2 29%
Researcher 1 14%
Other 1 14%
Unspecified 1 14%
Other 0 0%
Readers by discipline Count As %
Unspecified 2 29%
Agricultural and Biological Sciences 2 29%
Psychology 1 14%
Chemistry 1 14%
Medicine and Dentistry 1 14%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2018.
All research outputs
#1,037,505
of 12,651,470 outputs
Outputs from Psychopharmacology
#274
of 4,176 outputs
Outputs of similar age
#25,432
of 234,024 outputs
Outputs of similar age from Psychopharmacology
#7
of 61 outputs
Altmetric has tracked 12,651,470 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,176 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,024 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.