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Mitochondrial transporters for ornithine and related amino acids: a review

Overview of attention for article published in Amino Acids, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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5 tweeters

Citations

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17 Dimensions

Readers on

mendeley
43 Mendeley
Title
Mitochondrial transporters for ornithine and related amino acids: a review
Published in
Amino Acids, May 2015
DOI 10.1007/s00726-015-1990-5
Pubmed ID
Authors

Magnus Monné, Daniela Valeria Miniero, Lucia Daddabbo, Luigi Palmieri, Vito Porcelli, Ferdinando Palmieri

Abstract

Among the members of the mitochondrial carrier family, there are transporters that catalyze the translocation of ornithine and related substrates, such as arginine, homoarginine, lysine, histidine, and citrulline, across the inner mitochondrial membrane. The mitochondrial carriers ORC1, ORC2, and SLC25A29 from Homo sapiens, BAC1 and BAC2 from Arabidopsis thaliana, and Ort1p from Saccharomyces cerevisiae have been biochemically characterized by transport assays in liposomes. All of them transport ornithine and amino acids with side chains terminating at least with one amine. There are, however, marked differences in their substrate specificities including their affinity for ornithine (KM values in the mM to μM range). These differences are most likely reflected by minor differences in the substrate binding sites of these carriers. The physiological role of the above-mentioned mitochondrial carriers is to link several metabolic pathways that take place partly in the cytosol and partly in the mitochondrial matrix and to provide basic amino acids for mitochondrial translation. In the liver, human ORC1 catalyzes the citrulline/ornithine exchange across the mitochondrial inner membrane, which is required for the urea cycle. Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids. BAC1 and BAC2 are implicated in some processes similar to those of their human counterparts and in nitrogen and amino acid metabolism linked to stress conditions and the development of plants. Ort1p is involved in the biosynthesis of arginine and polyamines in yeast.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 30%
Unspecified 8 19%
Student > Ph. D. Student 4 9%
Other 3 7%
Student > Doctoral Student 3 7%
Other 12 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 35%
Agricultural and Biological Sciences 12 28%
Unspecified 11 26%
Computer Science 1 2%
Nursing and Health Professions 1 2%
Other 3 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2015.
All research outputs
#3,469,209
of 12,226,226 outputs
Outputs from Amino Acids
#291
of 1,015 outputs
Outputs of similar age
#72,274
of 232,067 outputs
Outputs of similar age from Amino Acids
#7
of 41 outputs
Altmetric has tracked 12,226,226 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,015 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,067 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.