| Title |
Surface functionalization by covalent immobilization of an innovative carvacrol derivative to avoid fungal biofilm formation
|
|---|---|
| Published in |
AMB Express, February 2015
|
| DOI | 10.1186/s13568-014-0091-2 |
| Pubmed ID | |
| Authors |
Aïcha Gharbi, Thibaut Legigan, Vincent Humblot, Sébastien Papot, Jean-Marc Berjeaud |
| Abstract |
Carvacrol, an aromatic terpenic compound, known to be antimicrobial was grafted onto gold surfaces via two strategies based on newly-synthesized cross-linkers involving either an ester bond which can be cleaved by microbial esterases, or a covalent ether link. Surface functionalizations were characterized at each step by reflection absorption infrared spectroscopy (RAIRS). The two functionalized gold samples both led to a loss of culturability of the yeast Candida albicans, higher than 65%, indicating that the activity of the freshly-designed surfaces was probably due to still covalently immobilized carvacrol. On the contrary, when a phenyl group replaced the terpenic moiety, the yeast culturability increased by about 30%, highlighting the specific activity of carvacrol grafted on the surfaces. Confocal microscopy analyses showed that the mode of action of the functionalized surfaces with the ester or the ether of carvacrol was, in both cases, fungicidal and not anti-adhesive. Finally, this study shows that covalently immobilization of terpenic compounds can be used to design promising antimicrobial surfaces. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 3 | 12% |
| Researcher | 3 | 12% |
| Student > Ph. D. Student | 3 | 12% |
| Other | 2 | 8% |
| Student > Bachelor | 2 | 8% |
| Other | 4 | 15% |
| Unknown | 9 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 5 | 19% |
| Agricultural and Biological Sciences | 3 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 8% |
| Environmental Science | 1 | 4% |
| Immunology and Microbiology | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 11 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from AMB Express
#968
of 1,234 outputs
Outputs of similar age
#296,388
of 352,241 outputs
Outputs of similar age from AMB Express
#16
of 17 outputs
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So far Altmetric has tracked 1,234 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.