| Title |
Response of oxidative stress and inflammatory biomarkers to a 12-week aerobic exercise training in women with metabolic syndrome
|
|---|---|
| Published in |
Sports Medicine - Open, April 2015
|
| DOI | 10.1186/s40798-015-0011-2 |
| Pubmed ID | |
| Authors |
Juliano Boufleur Farinha, Flávia Mariel Steckling, Sílvio Terra Stefanello, Manuela Sangoi Cardoso, Larissa Santos Nunes, Rômulo Pillon Barcelos, Thiago Duarte, Nélson Alexandre Kretzmann, Carlos Bolli Mota, Guilherme Bresciani, Rafael Noal Moresco, Marta Maria Medeiros Frescura Duarte, Daniela Lopes dos Santos, Félix Alexandre Antunes Soares |
| Abstract |
Evidences have been highlighted the relationship among metabolic syndrome, chronic low-grade inflammation, oxidative stress and several diseases. In this sense, the aim of this study was to investigate the effects of aerobic exercise training on oxidative stress and inflammatory parameters on women with metabolic syndrome (MS). Twenty-three untrained women (51.86 ± 6.58 years old, BMI 30.8 ± 4.3 kg/m(2)) completed a 12-week treadmill exercise training, without modifications on dietary pattern. Advanced oxidation protein products (AOPP), thiobarbituric acid-reactive substances (TBARS), total thiol content (T-SH) and nitrite and nitrate (NOx) levels were assessed in plasma while the levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α) and interferon-gamma (IFN-γ) were evaluated in the serum. The RNA expression (mRNA) of IL-1β, IL-10, TNF-α, IFN-γ, insulin receptor substrate 2 (IRS-2) and matrix metalloproteinase-9 (MMP-9) were performed inperipheral blood mononuclear cells (PBMC) of a subset with eight women with MS using real real-time polymerase chain reaction (qPCR). The intervention resulted in decreased serum levels of IL-1β, IL-6, TNF-α, IFN-γ, AOPP and TBARS, besides increased levels of IL-10 and T-SH (P < 0.001). NOx concentrations were unchanged, similarly to mRNA expressions quantified in PBMC. Twelve weeks of AT improved systemic oxidative stress and inflammatory biomarkers in women with MS, although PBMC mRNA expression for inflammatory pathways appeared to be unchanged. This may indicate that AT induced beneficial effects not only in physical fitness but also on health promotion through decreased oxidative damage and proinflammatory status. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 3 | 33% |
| Argentina | 1 | 11% |
| Switzerland | 1 | 11% |
| United States | 1 | 11% |
| Guatemala | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Scientists | 1 | 11% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 116 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 16% |
| Student > Bachelor | 16 | 14% |
| Student > Ph. D. Student | 13 | 11% |
| Professor | 6 | 5% |
| Student > Doctoral Student | 6 | 5% |
| Other | 22 | 19% |
| Unknown | 36 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 15% |
| Sports and Recreations | 18 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 11% |
| Agricultural and Biological Sciences | 9 | 8% |
| Nursing and Health Professions | 5 | 4% |
| Other | 15 | 13% |
| Unknown | 40 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2019.
All research outputs
#7,214,124
of 22,803,211 outputs
Outputs from Sports Medicine - Open
#355
of 470 outputs
Outputs of similar age
#86,629
of 264,931 outputs
Outputs of similar age from Sports Medicine - Open
#10
of 12 outputs
Altmetric has tracked 22,803,211 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 470 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.