| Title |
Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study
|
|---|---|
| Published in |
Clinical and Translational Medicine, April 2015
|
| DOI | 10.1186/s40169-015-0058-1 |
| Pubmed ID | |
| Authors |
Dieudonne Nanfa, Eugene Sobngwi, Barbara Atogho-Tiedeu, Jean Jacques N Noubiap, Olivier Sontsa Donfack, Edith Pascale Mato Mofo, Magellan Guewo-Fokeng, Aurelie Nguimmo Metsadjio, Elvis Ndonwi Ngwa, Priscille Pokam Fosso, Eric Djahmeni, Rosine Djokam-Dadjeu, Marie-Solange Evehe, Folefac Aminkeng, Wilfred F Mbacham, Jean Claude Mbanya |
| Abstract |
To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population. This case-control study included 60 T2DM patients and 60 healthy normoglycemic controls, all unrelated and of Cameroonian origin, aged above 40 years (range 40-87). The Restriction Fragment Length Polymorphism - Polymerase Chain Reaction (RFLP-PCR) was used for genotyping. The T allele frequency was significantly higher in the diabetic group (0.44) than in the control group (0.17). This allele was significantly associated to a greater risk of developing T2DM as compared to the G allele (OR = 3.92, 95% CI 2.04 - 7.67, p < 0.0001). The codominant (additive) model explained best the risk of developing the disease, as the TT genotype was significantly associated to T2DM when compared to the GG genotype (OR = 4.45, 95% CI 1.64 - 12.83, p = 0.0014). By logistic regression adjusted for age, this OR was 4.33 (95% CI: 1.57 - 11.92, p = 0.005). Our findings suggest that the rs12255372 (G/T) polymorphism of the TCF7L2 gene is an important risk factor for T2DM in the Cameroonian population. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 23% |
| Student > Ph. D. Student | 9 | 19% |
| Student > Bachelor | 5 | 11% |
| Student > Doctoral Student | 3 | 6% |
| Researcher | 3 | 6% |
| Other | 11 | 23% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 30% |
| Medicine and Dentistry | 13 | 28% |
| Agricultural and Biological Sciences | 6 | 13% |
| Computer Science | 2 | 4% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 9 | 19% |
Attention Score in Context
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#17,285,668
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Outputs from Clinical and Translational Medicine
#571
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#169,748
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Outputs of similar age from Clinical and Translational Medicine
#3
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