Title |
Tunneling nanotubes between rat primary astrocytes and C6 glioma cells alter proliferation potential of glioma cells
|
---|---|
Published in |
Neuroscience Bulletin, April 2015
|
DOI | 10.1007/s12264-014-1522-4 |
Pubmed ID | |
Authors |
Lei Zhang, Yan Zhang |
Abstract |
The tunneling nanotube (TNT) is a newly discovered, long and thin tubular structure between cells. In this study, we established a co-culture system for rat primary astrocytes and C6 glioma cells and found that TNTs formed between them. Most of the TNTs initiated from astrocytes towards C6 glioma cells. The formation of TNTs depended on p53. In addition, hydrogen peroxide increased the number of TNTs in the co-culture system. Established TNTs reduced the proliferation of C6 glioma cells. Our data suggest that TNTs between astrocytes and glioma cells facilitate substance transfer and therefore alter the properties, including the proliferation potential, of glioma cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 25% |
Student > Master | 10 | 14% |
Researcher | 8 | 12% |
Student > Bachelor | 7 | 10% |
Other | 4 | 6% |
Other | 6 | 9% |
Unknown | 17 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 20% |
Agricultural and Biological Sciences | 10 | 14% |
Medicine and Dentistry | 6 | 9% |
Neuroscience | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 9 | 13% |
Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2015.
All research outputs
#18,407,102
of 22,800,560 outputs
Outputs from Neuroscience Bulletin
#491
of 767 outputs
Outputs of similar age
#193,139
of 265,105 outputs
Outputs of similar age from Neuroscience Bulletin
#6
of 10 outputs
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