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Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures

Overview of attention for article published in Molecular and Cellular Biochemistry, September 2011
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  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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2 tweeters

Citations

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40 Dimensions

Readers on

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39 Mendeley
Title
Time-sequential modulation in expression of growth factors from platelet-rich plasma (PRP) on the chondrocyte cultures
Published in
Molecular and Cellular Biochemistry, September 2011
DOI 10.1007/s11010-011-1081-1
Pubmed ID
Authors

Se-Il Park, Hye-Rim Lee, Sukyoung Kim, Myun-Whan Ahn, Sun Hee Do

Abstract

Platelets are involved in hemostasis, wound healing, and tumor growth. Autologous blood products are commonly used to facilitate healing in a variety of clinical surgery applications. Recently, it was shown that platelet-rich plasma (PRP) has more specific growth factors that participate in the healing process. This study investigated the expression of PRP growth factors and evaluated their potential role in the cartilage regeneration using primary isolated chondrocytes. PRP obtained from New Zealand White rabbit by low speed centrifugation. Extracted PRPs contained 6-10 × 10(6) platelet/μl and concentration of platelets was slightly variable. Primary isolated chondrocytes from the same rabbits were cultured and treated with 0.1-20% PRP. The cells were collected and examined by reverse transcription-polymerase chain reaction and cytochemical staining. The expression of sex determining region Y-box 9, transforming growth factor-beta, vascular endothelial growth factor, and chondromdulin-I was increased in chondrocyte cultures with 10% PRP by time-dependent manner. To maintain the integrity of the cartilage, the proteoglycan contents were also up-regulated from the mRNA of aggrecan and positive Safranin-O staining in PRP concentration- and time-dependent manner. PRP provides crucial growth factors related to chondrocyte proliferation and differentiation through time-sequential modulation. Controlled in vivo trials for cartilage regeneration are needed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Japan 1 3%
United States 1 3%
Unknown 36 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 26%
Student > Ph. D. Student 8 21%
Other 4 10%
Student > Doctoral Student 4 10%
Student > Postgraduate 4 10%
Other 9 23%
Readers by discipline Count As %
Medicine and Dentistry 19 49%
Agricultural and Biological Sciences 7 18%
Unspecified 4 10%
Biochemistry, Genetics and Molecular Biology 2 5%
Engineering 2 5%
Other 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2011.
All research outputs
#7,400,602
of 12,325,396 outputs
Outputs from Molecular and Cellular Biochemistry
#902
of 1,550 outputs
Outputs of similar age
#56,487
of 96,435 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#4
of 15 outputs
Altmetric has tracked 12,325,396 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,550 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,435 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.