Title |
Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
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Published in |
Diabetologia, June 2013
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DOI | 10.1007/s00125-013-2955-4 |
Pubmed ID | |
Authors |
Jennifer E. Bruin, Alireza Rezania, Jean Xu, Kavitha Narayan, Jessica K. Fox, John J. O’Neil, Timothy J. Kieffer |
Abstract |
Islet transplantation is a promising cell therapy for patients with diabetes, but it is currently limited by the reliance upon cadaveric donor tissue. We previously demonstrated that human embryonic stem cell (hESC)-derived pancreatic progenitor cells matured under the kidney capsule in a mouse model of diabetes into glucose-responsive insulin-secreting cells capable of reversing diabetes. However, the formation of cells resembling bone and cartilage was a major limitation of that study. Therefore, we developed an improved differentiation protocol that aimed to prevent the formation of off-target mesoderm tissue following transplantation. We also examined how variation within the complex host environment influenced the development of pancreatic progenitors in vivo. |
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Geographical breakdown
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Australia | 1 | <1% |
Egypt | 1 | <1% |
Singapore | 1 | <1% |
Belgium | 1 | <1% |
United States | 1 | <1% |
Unknown | 232 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 59 | 25% |
Researcher | 40 | 17% |
Student > Bachelor | 30 | 13% |
Student > Master | 26 | 11% |
Other | 11 | 5% |
Other | 37 | 16% |
Unknown | 34 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 64 | 27% |
Agricultural and Biological Sciences | 48 | 20% |
Medicine and Dentistry | 35 | 15% |
Engineering | 20 | 8% |
Immunology and Microbiology | 5 | 2% |
Other | 22 | 9% |
Unknown | 43 | 18% |